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Literature DB >> 271964

High resolution two-dimensional electrophoresis of human plasma proteins.

Abstract

The two-dimensional electrophoretic technique of O'Farrell has been adapted to the analysis of human plasma proteins, and 30 polypeptides have been identified in the pattern produced. Genetic variants involving charge (isoelectric point) or size (molecular weight in the presence of sodium dodecyl sulfate) changes should be routinely detectable in at least 20 proteins at once, facilitating studies of human mutation rates.

Entities: Chemical Species

Mesh：

Substances：
Blood Proteins

Year: 1977 PMID： 271964 PMCID： PMC431746 DOI： 10.1073/pnas.74.12.5421

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. Two-dimensional gel analysis of soluble proteins. Charaterization of guinea pig exocrine pancreatic proteins.

Authors: G A Scheele
Journal: J Biol Chem Date: 1975-07-25 Impact factor: 5.157

2. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors: B J DAVIS
Journal: Ann N Y Acad Sci Date: 1964-12-28 Impact factor: 5.691

3. ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.

Authors: C B LAURELL
Journal: Anal Biochem Date: 1965-02 Impact factor: 3.365

4. Acrylamide gel as a supporting medium for zone electrophoresis.

Authors: S RAYMOND; L WEINTRAUB
Journal: Science Date: 1959-09-18 Impact factor: 47.728

Review 5. Lipoproteins: structure and function.

Authors: J D Morrisett; R L Jackson; A M Gotto
Journal: Annu Rev Biochem Date: 1975 Impact factor: 23.643

6. Electrophoresis of serum globulin. I.

Authors: A Tiselius
Journal: Biochem J Date: 1937-02 Impact factor: 3.857

7. High resolution two-dimensional electrophoresis of proteins.

Authors: P H O'Farrell
Journal: J Biol Chem Date: 1975-05-25 Impact factor: 5.157

8. Isoelectric focusing of serum proteins in acrylamide gels followed by electrophoresis.

Authors: G Dale; A L Latner
Journal: Clin Chim Acta Date: 1969-04 Impact factor: 3.786

9. Unexpected mobility of human lambda chains in sodium dodecyl sulphate-polyacrylamide gel electrophoresis.

Authors: G Virella; I M Coelho
Journal: Immunochemistry Date: 1974-03

10. Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells.

Authors: R A Steinberg; P H O'Farrell; U Friedrich; P Coffino
Journal: Cell Date: 1977-03 Impact factor: 41.582

102 in total

1. Use of two-dimensional gel electrophoresis to measure changes in synovial fluid proteins from patients with rheumatoid arthritis treated with antibody to CD4.

Authors: M A Smith; S K Bains; J C Betts; E H Choy; E D Zanders
Journal: Clin Diagn Lab Immunol Date: 2001-01

2. Reevaluation of level of genic heterozygosity in natural population of Drosophila melanogaster by two-dimensional electrophoresis.

Authors: A J Brown; C H Langley
Journal: Proc Natl Acad Sci U S A Date: 1979-05 Impact factor: 11.205

3. Combining isoelectric point-based fractionation, liquid chromatography and mass spectrometry to improve peptide detection and protein identification.

Authors: Stephanie M Cologna; William K Russell; Peniel J Lim; Gyula Vigh; David H Russell
Journal: J Am Soc Mass Spectrom Date: 2010-04-24 Impact factor: 3.109

4. Two-dimensional electrophoresis of synovial tissue, synovial fluid and serum in patients with rheumatoid arthritis and related diseases.

Authors: P Fritz; N Arold; A Mischlinski; H Wisser; B Oeffinger; V Neuhoff; W Laschner; G Koenig
Journal: Rheumatol Int Date: 1990 Impact factor: 2.631

10. Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of "edge effect" and cultivating an ethical bridge between omics innovations and society.

Authors: Vural Ozdemir; Guilherme Suarez-Kurtz; Raphaëlle Stenne; Andrew A Somogyi; Toshiyuki Someya; S Oğuz Kayaalp; Eugene Kolker
Journal: OMICS Date: 2009-02