Literature DB >> 293708

Action of cathepsin D on human beta-lipotropin: a possible source of human "beta-melanotropin".

E Barát, A Patthy, L Gráf.   

Abstract

Highly purified calf brain cathepsin D (EC 3.4.23.5) selectively splits the Leu77-Phe78 and Ala36-Ala37 peptide bonds of human beta-lipotropin. It is suggested that the formation of human "beta-melanotropin" from gamma-lipotropin, and that of gamma-endorphin from beta-endorphin, is due to the action of cathepsin D during isolation procedures.

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Year:  1979        PMID： 293708      PMCID： PMC411814          DOI： 10.1073/pnas.76.12.6120

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Chromatographic isolations of pig and human melanocyte-stimulating hormones.

Authors:  H B DIXON
Journal:  Biochim Biophys Acta       Date:  1960-01-01

2.  Primary structure of human beta-lipotropin.

Authors:  C H Li; D Chung
Journal:  Nature       Date:  1976-04-15       Impact factor: 49.962

3.  Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands.

Authors:  C H Li; L Barnafi; M Chrétien; D Chung
Journal:  Nature       Date:  1965-12-11       Impact factor: 49.962

4.  Action of plasmin on ovine beta-lipotropin: revision of the carboxyl terminal sequence.

Authors:  L Gráf; C H Li
Journal:  Biochem Biophys Res Commun       Date:  1973-08-21       Impact factor: 3.575

Review 5.  Strategy and tactics in protein chemistry.

Authors:  B S Hartley
Journal:  Biochem J       Date:  1970-10       Impact factor: 3.857

6.  Isolation and characterization of beta-lipolytic hormone from porcine pituitary gland.

Authors:  C Gilardeau; M Chrétien
Journal:  Can J Biochem       Date:  1970-09

7.  Amino acid sequence of porcine beta-lipotropic hormone.

Authors:  C Sajgó; L Gráf; E Barát; M Sajgó
Journal:  Biochim Biophys Acta       Date:  1971-01-19

8.  Common precursor to corticotropins and endorphins.

Authors:  R E Mains; B A Eipper; N Ling
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

9.  In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia.

Authors:  N G Seidah; C Gianoulakis; P Crine; M Lis; S Benjannet; R Routhier; M Chrétien
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

10.  Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary.

Authors:  A P Scott; P J Lowry
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857
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  6 in total

1.  Cathepsin D activity in human peripheral blood mononuclear leukocytes.

Authors:  C T Bever; K D Morgan; J N Whitaker
Journal:  Inflammation       Date:  1989-06       Impact factor: 4.092

2.  Immunoelectron microscopic localization of cathepsin D in lysosomes of rat nerve cells.

Authors:  S Yokota; S Atsumi
Journal:  Histochemistry       Date:  1983

Review 3.  Pituitary endopeptidases.

Authors:  M Orlowski
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

4.  Developmental changes in the breakdown of brain tubulin by cerebral cathepsin D.

Authors:  M Banay-Schwartz; F Bracco; T DeGuzman; A Lajtha
Journal:  Neurochem Res       Date:  1983-01       Impact factor: 3.996

5.  Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons.

Authors:  Nady Braidy; Bruce J Brew; Nibaldo C Inestrosa; Roger Chung; Perminder Sachdev; Gilles J Guillemin
Journal:  Metab Brain Dis       Date:  2014-05-16       Impact factor: 3.584

6.  Human beta-melanocyte-stimulating hormone revisited.

Authors:  X Bertagna; F Lenne; D Comar; J F Massias; H Wajcman; V Baudin; J P Luton; F Girard
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205
  6 in total

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