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Literature DB >> 4368382

Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary.

Abstract

The adrenocorticotrophic and melanocyte-stimulating peptides of the human pituitary were investigated by means of radioimmunoassay, bioassay and physicochemical procedures. Substantial amounts of adrenocorticotrophin and a peptide resembling beta-lipotrophin were identified in pituitary extracts, but alpha-melanocyte-stimulating hormone, beta-melanocyte-stimulating hormone and corticotrophin-like intermediate lobe peptide, which have been identified in the pars intermedia of pituitaries from other vertebrates, were not found. The absence of beta-melanocyte-stimulating hormone appears to contradict previous chemical and radioimmunological studies. Our results suggest, however, that it is not a natural pituitary peptide but an artefact formed by enzymic degradation of beta-lipotrophin during extraction.

Entities: Gene Species

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Year: 1974 PMID： 4368382 PMCID： PMC1166323 DOI： 10.1042/bj1390593

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

24 in total

1. Isolated adrenal cells: ACTH(11-24), a competitive antagonist of ACTH(1-39) and ACTH(1-10).

Authors: S Seelig; G Sayers; R Schwyzer; P Schiller
Journal: FEBS Lett Date: 1971-12-15 Impact factor: 4.124

2. A METHOD FOR SEPARATING SMALL QUANTITIES OF MSH AND ACTH WITH GOOD RECOVERY OF EACH.

Authors: D P ISLAND; N SHIMIZU; W E NICHOLSON; K ABE; E OGATA; G W LIDDLE
Journal: J Clin Endocrinol Metab Date: 1965-07 Impact factor: 5.958

3. Chromatographic isolations of pig and human melanocyte-stimulating hormones.

Authors: H B DIXON
Journal: Biochim Biophys Acta Date: 1960-01-01

4. On the structure of human corticotropin (adrenocorticotropic hormone).

Authors: T H LEE; A B LERNER; V BUETTNER-JANUSCH
Journal: J Biol Chem Date: 1961-11 Impact factor: 5.157

5. Some aspects of the relationship between chemical structure and melanocyte-stimulating properties of several peptides related to adrenocorticotropin.

Authors: B T PICKERING; C H LI
Journal: Biochim Biophys Acta Date: 1962-08-27

6. Properties of a simplified bioassay for adrenocorticotrophic activity using the steroidogenic response of isolated adrenal cells.

Authors: P J Lowry; C McMartin; J Peters
Journal: J Endocrinol Date: 1973-10 Impact factor: 4.286

7. In vitro assay of MSH using skin from the frog Hyla arborea.

Authors: A Chadwick; P J Lowry
Journal: Gen Comp Endocrinol Date: 1970-12 Impact factor: 2.822

8. Interrelations of some pituitary hormones.

Authors: P J Lowry; A Chadwick
Journal: Nature Date: 1970-04-18 Impact factor: 49.962

9. Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands.

Authors: C H Li; L Barnafi; M Chrétien; D Chung
Journal: Nature Date: 1965-12-11 Impact factor: 49.962

10. Normal and abnormal regulation of beta-msh in man.

Authors: K Abe; W E Nicholson; G W Liddle; D N Orth; D P Island
Journal: J Clin Invest Date: 1969-08 Impact factor: 14.808

32 in total

1. An abnormality in sebaceous function in phenylketonuria.

Authors: J L Burton; S K Goolamali; S Shuster
Journal: Br Med J Date: 1975-01-04

2. beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.

Authors: L H Lazarus; N Ling; R Guillemin
Journal: Proc Natl Acad Sci U S A Date: 1976-06 Impact factor: 11.205

3. Plasma immunoreactive melanotrophic hormones in patients on maintenance haemodialysis.

Authors: J J Gilkes; R A Eady; L H Rees; D D Munro; J F Moorhead
Journal: Br Med J Date: 1975-03-22

4. Decreased sebum excretion in chronic renal failure.

Authors: S Shuster; S K Goolamali; A G Smith; A J Thody; F Alvarez-Ude; D N Kerr
Journal: Br Med J Date: 1976-01-03

5. Characterization of a common precursor to corticotropin and beta-lipotropin: cell-free synthesis of the precursor and identification of corticotropin peptides in the molecule.

Authors: J L Roberts; E Herbert
Journal: Proc Natl Acad Sci U S A Date: 1977-11 Impact factor: 11.205

6. beta-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: lack of significant beta-endorphin.

Authors: A S Liotta; T Suda; D T Krieger
Journal: Proc Natl Acad Sci U S A Date: 1978-06 Impact factor: 11.205