Literature DB >> 29366899

Inulin based glutathione-responsive delivery system for colon cancer treatment.

Dongdong Wang1, Feifei Sun1, Chunbo Lu1, Peng Chen1, Zhaojie Wang1, Yuanhao Qiu1, Haibo Mu1, Zehong Miao2, Jinyou Duan3.   

Abstract

Colorectal cancer is one of the most common types of tumor in the world. Here we developed a lipoic acid esterified polysaccharide (inulin) delivery system for tanshinone IIA to treat colorectal cancer in vitro. The release of tanshinone IIA in the system was highly responsive to glutathione, which is commonly abundant in cancer cells. In addition, this drug delivery system was proliferative to Bifidobacterium longum, the common inhabitant of human intestine. Thus, this strategy might be useful to improve colon cancer therapy efficacy of anticancer drugs and meanwhile promote the growth of beneficial commensal flora in the gut.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Colorectal cancer; Inulin; Lipoic acid; Polymeric micelles; Probiotic

Mesh：

Substances：

Year:  2018        PMID： 29366899     DOI： 10.1016/j.ijbiomac.2018.01.071

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  6 in total

1.  Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome-gut-brain axis modulation.

Authors:  Shokouh Ahmadi; Ravinder Nagpal; Shaohua Wang; Jason Gagliano; Dalane W Kitzman; Sabihe Soleimanian-Zad; Mahmoud Sheikh-Zeinoddin; Russel Read; Hariom Yadav
Journal:  J Nutr Biochem       Date:  2019-01-30       Impact factor: 6.048

Review 2.  Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review.

Authors:  Muhammad Usman; Chengnan Zhang; Prasanna Jagannath Patil; Arshad Mehmood; Xiuting Li; Muhammad Bilal; Junaid Haider; Shabbir Ahmad
Journal:  Carbohydr Polym       Date:  2020-10-06       Impact factor: 9.381

Review 3.  Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy.

Authors:  Runqi Zhu; Tianqun Lang; Wenlu Yan; Xiao Zhu; Xin Huang; Qi Yin; Yaping Li
Journal:  Adv Sci (Weinh)       Date:  2021-03-09       Impact factor: 16.806

Review 4.  Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies.

Authors:  Md Sanower Hossain; Hidayah Karuniawati; Ammar Abdulrahman Jairoun; Zannat Urbi; Der Jiun Ooi; Akbar John; Ya Chee Lim; K M Kaderi Kibria; A K M Mohiuddin; Long Chiau Ming; Khang Wen Goh; Muhammad Abdul Hadi
Journal:  Cancers (Basel)       Date:  2022-03-29       Impact factor: 6.639

5.  Novel targeting approaches and signaling pathways of colorectal cancer: An insight.

Authors:  Ankita Tiwari; Shivani Saraf; Amit Verma; Pritish Kumar Panda; Sanjay K Jain
Journal:  World J Gastroenterol       Date:  2018-10-21       Impact factor: 5.742

6.  Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice.

Authors:  Li-Li Li; Yu-Ting Wang; Li-Meng Zhu; Zheng-Yi Liu; Chang-Qing Ye; Song Qin
Journal:  Sci Rep       Date:  2020-01-22       Impact factor: 4.379
  6 in total

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