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Literature DB >> 34026439

Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy.

Runqi Zhu^1,2, Tianqun Lang^1,2,3, Wenlu Yan^1,2, Xiao Zhu^1,2, Xin Huang^1,2, Qi Yin^1,2,3, Yaping Li^1,2,3,4.

Abstract

Gut microbiota have close interactions with the host. It can affect cancer progression and the outcomes of cancer therapy, including chemotherapy, immunotherapy, and radiotherapy. Therefore, approaches toward the modulation of gut microbiota will enhance cancer prevention and treatment. Modern drug delivery systems (DDS) are emerging as rational and promising tools for microbiota intervention. These delivery systems have compensated for the obstacles associated with traditional treatments. In this review, the essential roles of gut microbiota in carcinogenesis, cancer progression, and various cancer therapies are first introduced. Next, advances in DDS that are aimed at enhancing the efficacy of cancer therapy by modulating or engineering gut microbiota are highlighted. Finally, the challenges and opportunities associated with the application of DDS targeting gut microbiota for cancer prevention and treatment are briefly discussed.

Entities: Chemical

Keywords: cancer therapy; carcinogenesis; drug delivery system; gut microbiota; modulation

Mesh：

Year: 2021 PMID： 34026439 PMCID： PMC8132165 DOI： 10.1002/advs.202003542

Source DB: PubMed Journal: Adv Sci (Weinh) ISSN： 2198-3844 Impact factor: 16.806

250 in total

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2. The human gut bacterial genotoxin colibactin alkylates DNA.

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5. Genetic alterations in colorectal cancer.

Authors: Tannaz Armaghany; Jon D Wilson; Quyen Chu; Glenn Mills
Journal: Gastrointest Cancer Res Date: 2012-01

6. Metabolic Model-Based Integration of Microbiome Taxonomic and Metabolomic Profiles Elucidates Mechanistic Links between Ecological and Metabolic Variation.

Authors: Cecilia Noecker; Alexander Eng; Sujatha Srinivasan; Casey M Theriot; Vincent B Young; Janet K Jansson; David N Fredricks; Elhanan Borenstein
Journal: mSystems Date: 2016-01-19 Impact factor: 6.496

7. Clinical significance of Fusobacterium nucleatum, epithelial-mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients.

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8. Bioinspired oral delivery of gut microbiota by self-coating with biofilms.

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Review 9. Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body.

Authors: Régis Stentz; Ana L Carvalho; Emily J Jones; Simon R Carding
Journal: Biochem Soc Trans Date: 2018-08-28 Impact factor: 5.407

10. Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway.

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4 in total

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