Gwenaël Pagé1, Jérémie Bettoni2, Anne-Virginie Salsac3, Olivier Balédent4,5. 1. BioFlow Image, University Hospital of Amiens Picardy, Université de Picardie Jules Verne, Avenue Rene Laennec, Salouël, 80480, Amiens, France. gwenael.page@hotmail.fr. 2. Maxillo-Facial Surgery, University Hospital of Amiens-Picardie, Amiens, France. 3. Biomechanics and Bioengineering Laboratory (UMR CNRS 7338), Sorbonne Universités, Université de Technologie de Compiègne-CNRS, Compiègne, France. 4. BioFlow Image, University Hospital of Amiens Picardy, Université de Picardie Jules Verne, Avenue Rene Laennec, Salouël, 80480, Amiens, France. 5. Laboratory of Image Processing, University Hospital of Amiens-Picardie, Amiens, France.
Abstract
OBJECTIVE: The objective of the study was to determine how to optimize 2D and 4D phase-contrast magnetic resonance imaging (PC-MRI) acquisitions to acquire flow velocities in millimetric vessels. In particular, we search for the best compromise between acquisition time and accuracy and assess the influence of the principal component analysis (PCA). MATERIALS AND METHODS: 2D and 4D PC-MRI measurements are conducted within two in vitro vessel phantoms: a Y-bifurcation phantom, the branches of which range from 2 to 5 mm in diameter, and a physiological subject-specific phantom of the carotid bifurcation. The same sequences are applied in vivo in carotid vasculature. RESULTS: For a vessel oriented in the axial direction, both 2D and axial 4D PC-MRI provided accuracy measurements regardless of the k-t PCA factor, while the acquisition time is reduced by a factor 6 for k-t PCA maximum value. The in vivo measurements show that the proposed sequences are adequate to acquire 2D and 4D velocity fields in millimetric vessels and with clinically realistic time durations. CONCLUSION: The study shows the feasibility of conducting fast, high-resolution PC-MRI flow measurements in millimetric vessels and that it is worth maximizing the k-t PCA factor to reduce the acquisition time in the case of 2D and 4D axial acquisitions.
OBJECTIVE: The objective of the study was to determine how to optimize 2D and 4D phase-contrast magnetic resonance imaging (PC-MRI) acquisitions to acquire flow velocities in millimetric vessels. In particular, we search for the best compromise between acquisition time and accuracy and assess the influence of the principal component analysis (PCA). MATERIALS AND METHODS: 2D and 4D PC-MRI measurements are conducted within two in vitro vessel phantoms: a Y-bifurcation phantom, the branches of which range from 2 to 5 mm in diameter, and a physiological subject-specific phantom of the carotid bifurcation. The same sequences are applied in vivo in carotid vasculature. RESULTS: For a vessel oriented in the axial direction, both 2D and axial 4D PC-MRI provided accuracy measurements regardless of the k-t PCA factor, while the acquisition time is reduced by a factor 6 for k-t PCA maximum value. The in vivo measurements show that the proposed sequences are adequate to acquire 2D and 4D velocity fields in millimetric vessels and with clinically realistic time durations. CONCLUSION: The study shows the feasibility of conducting fast, high-resolution PC-MRI flow measurements in millimetric vessels and that it is worth maximizing the k-t PCA factor to reduce the acquisition time in the case of 2D and 4D axial acquisitions.
Keywords:
Cine MRI; Feasibility studies; Imaging phantoms; Principal component analysis
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