Literature DB >> 29339386

Pterostilbene, a Potential MCR-1 Inhibitor That Enhances the Efficacy of Polymyxin B.

Yonglin Zhou1, Shui Liu1, Tingting Wang1, Hui Li2, Shusheng Tang2, Jianfeng Wang1, Yang Wang3, Xuming Deng4.   

Abstract

We characterized the synergistic effect produced between pterostilbene and polymyxin B (fractional inhibitory concentration [FIC] index = 0.156 or 0.188) against MCR-producing Escherichia coli strains of both human and animal origins. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate the mcr-1- and NDM-positive E. coli strain ZJ487, but the combination eliminated the strain by 1 h postinoculation. The survival rate of mice after intraperitoneal infections was significantly enhanced from 0% to 60% in the group in which combination therapy was applied.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Enterobacteriaceae; MCR-1; inhibitor; polymyxin B; pterostilbene

Mesh：

Substances：

Year:  2018        PMID： 29339386      PMCID： PMC5913934          DOI： 10.1128/AAC.02146-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

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6.  Analysis of safety from a human clinical trial with pterostilbene.

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