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Literature DB >> 29337202

Progress with covalent small-molecule kinase inhibitors.

Abstract

With reduced risk of toxicity and high selectivity, covalent small-molecule kinase inhibitors (CSKIs) have emerged rapidly. Through the lens of structural system pharmacology, here we review this rapid progress by considering design strategies and the challenges and opportunities offered by current CSKIs.

Entities: Disease

Mesh：

Substances：

Year: 2018 PMID： 29337202 DOI： 10.1016/j.drudis.2018.01.035

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

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Cited

39 in total

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