Literature DB >> 29915817

Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.

Mu Yang1, Hanzhi Wu2, Julie Chu1, Lucas A Gabriel1, Y Kim3, Karen S Anderson3, Cristina M Furdui2, Ulrich Bierbach1.   

Abstract

Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue.

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Year:  2018        PMID： 29915817      PMCID： PMC7050444          DOI： 10.1039/c8cc04251a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

1.  A small molecule-kinase interaction map for clinical kinase inhibitors.

Authors:  Miles A Fabian; William H Biggs; Daniel K Treiber; Corey E Atteridge; Mihai D Azimioara; Michael G Benedetti; Todd A Carter; Pietro Ciceri; Philip T Edeen; Mark Floyd; Julia M Ford; Margaret Galvin; Jay L Gerlach; Robert M Grotzfeld; Sanna Herrgard; Darren E Insko; Michael A Insko; Andiliy G Lai; Jean-Michel Lélias; Shamal A Mehta; Zdravko V Milanov; Anne Marie Velasco; Lisa M Wodicka; Hitesh K Patel; Patrick P Zarrinkar; David J Lockhart
Journal:  Nat Biotechnol       Date:  2005-02-13       Impact factor: 54.908

Review 2.  Developing irreversible inhibitors of the protein kinase cysteinome.

Authors:  Qingsong Liu; Yogesh Sabnis; Zheng Zhao; Tinghu Zhang; Sara J Buhrlage; Lyn H Jones; Nathanael S Gray
Journal:  Chem Biol       Date:  2013-02-21

Review 3.  The Cysteinome of Protein Kinases as a Target in Drug Development.

Authors:  Apirat Chaikuad; Pierre Koch; Stefan A Laufer; Stefan Knapp
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-02       Impact factor: 15.336

Review 4.  Progress with covalent small-molecule kinase inhibitors.

Authors:  Zheng Zhao; Philip E Bourne
Journal:  Drug Discov Today       Date:  2018-01-11       Impact factor: 7.851

Review 5.  Epidermal growth factor receptor mutations in lung cancer.

Authors:  Sreenath V Sharma; Daphne W Bell; Jeffrey Settleman; Daniel A Haber
Journal:  Nat Rev Cancer       Date:  2007-03       Impact factor: 60.716

6.  Replacement of a thiourea-S with an amidine-NH donor group in a platinum-acridine antitumor compound reduces the metal's reactivity with cysteine sulfur.

Authors:  Zhidong Ma; Lu Rao; Ulrich Bierbach
Journal:  J Med Chem       Date:  2009-05-28       Impact factor: 7.446

Review 7.  The ErbB/HER family of protein-tyrosine kinases and cancer.

Authors:  Robert Roskoski
Journal:  Pharmacol Res       Date:  2013-11-20       Impact factor: 7.658

8.  Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase.

Authors:  Thu H Truong; Peter Man-Un Ung; Prakash B Palde; Candice E Paulsen; Avner Schlessinger; Kate S Carroll
Journal:  Cell Chem Biol       Date:  2016-07-14       Impact factor: 8.116

Review 9.  Overcoming drug resistance to receptor tyrosine kinase inhibitors: Learning from lung cancer.

Authors:  Michihiko Kuwano; Kahori Sonoda; Yuichi Murakami; Kosuke Watari; Mayumi Ono
Journal:  Pharmacol Ther       Date:  2016-03-18       Impact factor: 12.310

10.  A platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors.

Authors:  Yuming Wei; Daniel C Poon; Rong Fei; Amy S M Lam; Steve C F Au-Yeung; Kenneth K W To
Journal:  Sci Rep       Date:  2016-05-06       Impact factor: 4.379
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  1 in total

1.  Platinum(II) Terpyridine Anticancer Complexes Possessing Multiple Mode of DNA Interaction and EGFR Inhibiting Activity.

Authors:  Chaoyang Li; Fengmin Xu; Yao Zhao; Wei Zheng; Wenjuan Zeng; Qun Luo; Zhaoying Wang; Kui Wu; Jun Du; Fuyi Wang
Journal:  Front Chem       Date:  2020-04-28       Impact factor: 5.221
  1 in total

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