Literature DB >> 2933591

Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine.

N Brunello, A Volterra, R Cagiano, G C Ianieri, V Cuomo, G Racagni.   

Abstract

The decrease in the Bmax value of 3H-dihydroalprenolol (3H-DHA) binding to cortical membranes of rat brain induced by long-term administration of desipramine (DMI) was prevented by concomitant treatment with parachlorophenylalanine (pCPA). Acute administration of DMI significantly decreased locomotor activity in saline- and (pCPA)-pretreated rats. DMI-induced inhibition of locomotor activity was abolished in (pCPA)-pretreated rats chronically treated with DMI. Conversely, in pCPA-pretreated animals, acute DMI could still significantly decrease the locomotion of chronically DMI-treated rats. The data presented indicate that an intact serotoninergic system is required to enable antidepressant drugs to induce biochemical and behavioral changes following their chronic administration.

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Year:  1985        PMID： 2933591     DOI： 10.1007/BF00498847

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  18 in total

1.  Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain.

Authors:  J Vetulani; F Sulser
Journal:  Nature       Date:  1975-10-09       Impact factor: 49.962

2.  Development of beta-adrenergic receptor subsensitivity by antidepressants.

Authors:  S P Banerjee; L S Kung; S J Riggi; S K Chanda
Journal:  Nature       Date:  1977-08-04       Impact factor: 49.962

3.  Presynaptic alpha-receptor subsensitivity after long-term antidepressant treatment.

Authors:  F T Crews; C B Smith
Journal:  Science       Date:  1978-10-20       Impact factor: 47.728

4.  Behavioural changes after acute and chronic administration of typical and atypical antidepressants in rats: interactions with reserpine.

Authors:  V Cuomo; R Cagiano; N Brunello; R Fumagalli; G Racagni
Journal:  Neurosci Lett       Date:  1983-10-10       Impact factor: 3.046

5.  Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder.

Authors:  D S Segal; R Kuczenski; A J Mandell
Journal:  Biol Psychiatry       Date:  1974-10       Impact factor: 13.382

6.  In vivo studies on central noradrenergic synaptic mechanisms after acute and chronic antidepressant drug treatment: biochemical and behavioral comparison.

Authors:  G Racagni; I Mocchetti; G Renna; V Cuomo
Journal:  J Pharmacol Exp Ther       Date:  1982-10       Impact factor: 4.030

7.  Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment.

Authors:  D A Bergstrom; K J Kellar
Journal:  J Pharmacol Exp Ther       Date:  1979-05       Impact factor: 4.030

8.  Down-regulation of beta-adrenergic receptors following repeated injections of desmethylimipramine: permissive role of serotonergic axons.

Authors:  N Brunello; M L Barbaccia; D M Chuang; E Costa
Journal:  Neuropharmacology       Date:  1982-11       Impact factor: 5.250

9.  Simultaneous determination of femtomole quantities of 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in brain using HPLC with electrochemical detection.

Authors:  Z Lacković; M Parenti; N H Neff
Journal:  Eur J Pharmacol       Date:  1981-01-29       Impact factor: 4.432

10.  Effects of bicuculline and chlordiazepoxide on locomotor activity and avoidance performance in rats.

Authors:  V Cuomo; I Cortese
Journal:  Experientia       Date:  1980-10-15
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  3 in total

1.  An investigation of the role of 5-hydroxytryptamine in the attenuation of presynaptic alpha 2-adrenoceptor-mediated responses by antidepressant treatments.

Authors:  D J Heal; E M Hurst; M R Prow; W R Buckett
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

Review 2.  New perspectives on the molecular pharmacology of affective disorders.

Authors:  F Sulser
Journal:  Eur Arch Psychiatry Neurol Sci       Date:  1989

3.  Determination of the role of noradrenergic and 5-hydroxytryptaminergic neurones in postsynaptic alpha 2-adrenoceptor desensitization by desipramine and ECS.

Authors:  D J Heal; M R Prow; W R Buckett
Journal:  Br J Pharmacol       Date:  1991-08       Impact factor: 8.739
  3 in total

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