Literature DB >> 29333139

A framework for an alternatives assessment dashboard for evaluating chemical alternatives applied to flame retardants for electronic applications.

Todd M Martin1.   

Abstract

The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are compared using a variety of human health effects, ecotoxicity, and physicochemical properties. Hazard profiles are completed using a variety of online sources and quantitative structure activity relationship models. In the second stage, alternatives are evaluated utilizing an exposure/risk assessment over the entire life cycle. Exposure values are calculated using screening-level near-field and far-field exposure models. The second stage allows one to more accurately compare potential exposure to each alternative and consider additional factors that may not be obvious from separate binned persistence, bioaccumulation, and toxicity scores. The methodology was utilized to compare phosphate-based alternatives for decabromodiphenyl ether (decaBDE) in electronics applications.

Entities:  

Keywords:  Alternatives assessment; Ecotoxicity; Exposure; Human toxicity; Life cycle impact assessment

Year:  2017        PMID: 29333139      PMCID: PMC5759784          DOI: 10.1007/s10098-016-1300-2

Source DB:  PubMed          Journal:  Clean Technol Environ Policy        ISSN: 1618-954X            Impact factor:   3.636


  30 in total

1.  Fugacity-based indoor residential pesticide fate model.

Authors:  Deborah H Bennett; Edwin J Furtaw
Journal:  Environ Sci Technol       Date:  2004-04-01       Impact factor: 9.028

2.  The exposure data landscape for manufactured chemicals.

Authors:  Peter P Egeghy; Richard Judson; Sumit Gangwal; Shad Mosher; Doris Smith; James Vail; Elaine A Cohen Hubal
Journal:  Sci Total Environ       Date:  2011-11-21       Impact factor: 7.963

3.  Prediction of in vitro and in vivo oestrogen receptor activity using hierarchical clustering.

Authors:  T M Martin
Journal:  SAR QSAR Environ Res       Date:  2016-01-19       Impact factor: 3.000

4.  Risk-Based High-Throughput Chemical Screening and Prioritization using Exposure Models and in Vitro Bioactivity Assays.

Authors:  Hyeong-Moo Shin; Alexi Ernstoff; Jon A Arnot; Barbara A Wetmore; Susan A Csiszar; Peter Fantke; Xianming Zhang; Thomas E McKone; Olivier Jolliet; Deborah H Bennett
Journal:  Environ Sci Technol       Date:  2015-05-14       Impact factor: 9.028

5.  Bioaccumulation of organic contaminants in humans: a multimedia perspective and the importance of biotransformation.

Authors:  Michael S McLachlan; Gertje Czub; Matthew MacLeod; Jon A Arnot
Journal:  Environ Sci Technol       Date:  2010-08-11       Impact factor: 9.028

Review 6.  A global review of polybrominated diphenyl ether flame retardant contamination in birds.

Authors:  Da Chen; Robert C Hale
Journal:  Environ Int       Date:  2010-06-16       Impact factor: 9.621

7.  Multimedia modeling of human exposure to chemical substances: the roles of food web biomagnification and biotransformation.

Authors:  Jon A Arnot; Don Mackay; Thomas F Parkerton; Rosemary T Zaleski; Christopher S Warren
Journal:  Environ Toxicol Chem       Date:  2010-01       Impact factor: 3.742

8.  SHEDS-HT: an integrated probabilistic exposure model for prioritizing exposures to chemicals with near-field and dietary sources.

Authors:  Kristin K Isaacs; W Graham Glen; Peter Egeghy; Michael-Rock Goldsmith; Luther Smith; Daniel Vallero; Raina Brooks; Christopher M Grulke; Halûk Özkaynak
Journal:  Environ Sci Technol       Date:  2014-10-21       Impact factor: 9.028

9.  Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers.

Authors:  A Sjödin; L Hagmar; E Klasson-Wehler; K Kronholm-Diab; E Jakobsson; A Bergman
Journal:  Environ Health Perspect       Date:  1999-08       Impact factor: 9.031

10.  Prioritizing chemicals and data requirements for screening-level exposure and risk assessment.

Authors:  Jon A Arnot; Trevor N Brown; Frank Wania; Knut Breivik; Michael S McLachlan
Journal:  Environ Health Perspect       Date:  2012-09-20       Impact factor: 9.031

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  3 in total

1.  Linking Molecular Structure via Functional Group to Chemical Literature for Establishing a Reaction Lineage for Application to Alternatives Assessment.

Authors:  William M Barrett; Sudhakar Takkellapati; Kidus Tadele; Todd M Martin; Michael A Gonzalez
Journal:  ACS Sustain Chem Eng       Date:  2019-04-15       Impact factor: 8.198

2.  Framework towards more Sustainable Chemical Synthesis Design - A Case Study of Organophosphates.

Authors:  Michael A Gonzalez; Sudhakar Takkellapati; Kidus Tadele; Tao Li; Rajender S Varma
Journal:  ACS Sustain Chem Eng       Date:  2019-02-25       Impact factor: 8.198

3.  Combining In Silico Tools with Multicriteria Analysis for Alternatives Assessment of Hazardous Chemicals: Accounting for the Transformation Products of decaBDE and Its Alternatives.

Authors:  Ziye Zheng; Hans Peter H Arp; Gregory Peters; Patrik L Andersson
Journal:  Environ Sci Technol       Date:  2020-12-31       Impact factor: 9.028

  3 in total

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