Mark Peyrot1, Darlene Dreon2, Vivien Zraick2, Brett Cross2, Meng H Tan3. 1. Department of Sociology, Loyola University Maryland, Baltimore, MD, USA. mark.peyrot@gmail.com. 2. Calibra Medical, Wayne, PA, USA. 3. Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Abstract
INTRODUCTION: A basal-bolus insulin regimen is needed to achieve glycated hemoglobin A1c (HbA1c) below 7.0% in people with type 1 (T1D) or type 2 (T2D) diabetes who have significant loss of beta-cell function. Nonadherence to therapy is common and negatively affects the ability to reach treatment goals. We examined patient assessment of a new, wearable mealtime insulin-delivery system (patch) relative to their current mealtime insulin-delivery system (syringe, pen, or pump). The patch is designed to deliver only boluses of fast-acting insulin (no basal insulin), mechanically controlled by the patient. METHODS: Adults (n = 101) with T1D or T2D assessed their current mealtime insulin-delivery system and then assessed simulated (no active medication) patch use over a 3-day period. Participants evaluated mealtime insulin-delivery systems using eight measures from five domains (convenience, interference with daily activities, diabetes-related worry, psychological well-being, and overall satisfaction/preference) on the self-administered Insulin Delivery System Rating Questionnaire. User ratings of their current insulin-delivery systems (syringe, pen, pump) were compared with those for the patch by repeated measure analysis of variance and one-sample t tests. RESULTS: Participants had significant (p < 0.05) preference for patch over syringe in all eight comparisons, and over pen in five out of eight comparisons, with no significant preference for pen. Although there was a preference for patch over pump in six out of eight comparisons, only one showed a significant preference for patch, and one for pump. Significantly more participants reported that they would like to switch to the patch than continue using a syringe (78% vs 22%) or pen (76% vs 24%) but this difference was not significant for the group using a pump (52% vs 48%). CONCLUSIONS: Participants preferred using the patch over pens and syringes. Its ease of use and discreet method of insulin delivery may contribute to improved patient adherence to mealtime insulin regimens among people currently using injection devices. FUNDING: Calibra Medical.
INTRODUCTION: A basal-bolus insulin regimen is needed to achieve glycated hemoglobin A1c (HbA1c) below 7.0% in people with type 1 (T1D) or type 2 (T2D) diabetes who have significant loss of beta-cell function. Nonadherence to therapy is common and negatively affects the ability to reach treatment goals. We examined patient assessment of a new, wearable mealtime insulin-delivery system (patch) relative to their current mealtime insulin-delivery system (syringe, pen, or pump). The patch is designed to deliver only boluses of fast-acting insulin (no basal insulin), mechanically controlled by the patient. METHODS: Adults (n = 101) with T1D or T2D assessed their current mealtime insulin-delivery system and then assessed simulated (no active medication) patch use over a 3-day period. Participants evaluated mealtime insulin-delivery systems using eight measures from five domains (convenience, interference with daily activities, diabetes-related worry, psychological well-being, and overall satisfaction/preference) on the self-administered Insulin Delivery System Rating Questionnaire. User ratings of their current insulin-delivery systems (syringe, pen, pump) were compared with those for the patch by repeated measure analysis of variance and one-sample t tests. RESULTS:Participants had significant (p < 0.05) preference for patch over syringe in all eight comparisons, and over pen in five out of eight comparisons, with no significant preference for pen. Although there was a preference for patch over pump in six out of eight comparisons, only one showed a significant preference for patch, and one for pump. Significantly more participants reported that they would like to switch to the patch than continue using a syringe (78% vs 22%) or pen (76% vs 24%) but this difference was not significant for the group using a pump (52% vs 48%). CONCLUSIONS:Participants preferred using the patch over pens and syringes. Its ease of use and discreet method of insulin delivery may contribute to improved patient adherence to mealtime insulin regimens among people currently using injection devices. FUNDING: Calibra Medical.
Entities:
Keywords:
Diabetes mellitus; Insulin delivery; Patient preference; Quality of life
Authors: Nancy Bohannon; Richard Bergenstal; Robert Cuddihy; Davida Kruger; Susan List; Elaine Massaro; Mark Molitch; Philip Raskin; Heather Remtema; Suzanne Strowig; Fred Whitehouse; Rocco L Brunelle; Darlene Dreon; Meng Tan Journal: Diabetes Technol Ther Date: 2011-07-06 Impact factor: 6.118
Authors: Katharine D Barnard; Michael Bromba; Mirja de Lange; Marine Halbron; Brian L Levy; Marc Lévy; Bernhard Lippmann-Grob; Kieran Walshe; Ralph Ziegler Journal: J Diabetes Sci Technol Date: 2015-01-14
Authors: Richard M Bergenstal; Mary L Johnson; Vanita R Aroda; Ronald L Brazg; Darlene M Dreon; Juan P Frias; Davida F Kruger; Mark E Molitch; Deborah M Mullen; Mark Peyrot; Sara Richter; Julio Rosenstock; Pierre Serusclat; Carl Vance; Ruth S Weinstock; Brian L Levy Journal: J Diabetes Sci Technol Date: 2021-05-19