Literature DB >> 29325149

Anatomy of a Hotspot: Chain and Seroepidemiology of Ebola Virus Transmission, Sukudu, Sierra Leone, 2015-16.

J Daniel Kelly1,2, Mohamed Bailor Barrie2,3, Annelies W Mesman2, Sahr Karku2, Komba Quiwa2, Michael Drasher2, Gabriel Warren Schlough2, Kerry Dierberg2, Songor Koedoyoma4, Christina P Lindan5, James Holland Jones6, Gabriel Chamie7, Lee Worden8, Bryan Greenhouse7, Sheri D Weiser7, Travis C Porco5, George W Rutherford5, Eugene T Richardson2,3,9,10.   

Abstract

Studies have yet to include minimally symptomatic Ebola virus (EBOV) infections and unrecognized Ebola virus disease (EVD) in Ebola-related transmission chains and epidemiologic risk estimates. We conducted a cross-sectional, sero-epidemiological survey from October 2015 to January 2016 among 221 individuals living in quarantined households from November 2014 to February 2015 during the Ebola outbreak in the village of Sukudu, Sierra Leone. Of 48 EBOV-infected persons, 25% (95% confidence interval [CI], 14%-40%) had minimally symptomatic EBOV infections and 4% (95% CI, 1%-14%) were unrecognized EVD cases. The pattern of minimally symptomatic EBOV infections in the transmission chain was nonrandom (P < .001, permutation test). Not having lived in the same house as an EVD case was significantly associated with minimally symptomatic infection. This is the first study to investigate a chain of EBOV transmission inclusive of minimally symptomatic EBOV infections and unrecognized EVD. Our findings provide new insights into Ebola transmission dynamics and quarantine practices.

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Year:  2018        PMID： 29325149      PMCID： PMC6018898          DOI： 10.1093/infdis/jiy004

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  22 in total

1.  Estimating the future number of cases in the Ebola epidemic--Liberia and Sierra Leone, 2014-2015.

Authors:  Martin I Meltzer; Charisma Y Atkins; Scott Santibanez; Barbara Knust; Brett W Petersen; Elizabeth D Ervin; Stuart T Nichol; Inger K Damon; Michael L Washington
Journal:  MMWR Suppl       Date:  2014-09-26

2.  Human asymptomatic Ebola infection and strong inflammatory response.

Authors:  E M Leroy; S Baize; V E Volchkov; S P Fisher-Hoch; M C Georges-Courbot; J Lansoud-Soukate; M Capron; P Debré; J B McCormick; A J Georges
Journal:  Lancet       Date:  2000-06-24       Impact factor: 79.321

3.  Clinical illness and outcomes in patients with Ebola in Sierra Leone.

Authors:  John S Schieffelin; Jeffrey G Shaffer; Augustine Goba; Michael Gbakie; Stephen K Gire; Andres Colubri; Rachel S G Sealfon; Lansana Kanneh; Alex Moigboi; Mambu Momoh; Mohammed Fullah; Lina M Moses; Bethany L Brown; Kristian G Andersen; Sarah Winnicki; Stephen F Schaffner; Daniel J Park; Nathan L Yozwiak; Pan-Pan Jiang; David Kargbo; Simbirie Jalloh; Mbalu Fonnie; Vandi Sinnah; Issa French; Alice Kovoma; Fatima K Kamara; Veronica Tucker; Edwin Konuwa; Josephine Sellu; Ibrahim Mustapha; Momoh Foday; Mohamed Yillah; Franklyn Kanneh; Sidiki Saffa; James L B Massally; Matt L Boisen; Luis M Branco; Mohamed A Vandi; Donald S Grant; Christian Happi; Sahr M Gevao; Thomas E Fletcher; Robert A Fowler; Daniel G Bausch; Pardis C Sabeti; S Humarr Khan; Robert F Garry
Journal:  N Engl J Med       Date:  2014-10-29       Impact factor: 91.245

4.  High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon.

Authors:  Pierre Becquart; Nadia Wauquier; Tanel Mahlakõiv; Dieudonné Nkoghe; Cindy Padilla; Marc Souris; Benjamin Ollomo; Jean-Paul Gonzalez; Xavier De Lamballerie; Mirdad Kazanji; Eric M Leroy
Journal:  PLoS One       Date:  2010-02-09       Impact factor: 3.240

5.  Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia.

Authors:  Stephen B Kennedy; Fatorma Bolay; Mark Kieh; Greg Grandits; Moses Badio; Ripley Ballou; Risa Eckes; Mark Feinberg; Dean Follmann; Birgit Grund; Swati Gupta; Lisa Hensley; Elizabeth Higgs; Krisztina Janosko; Melvin Johnson; Francis Kateh; James Logue; Jonathan Marchand; Thomas Monath; Martha Nason; Tolbert Nyenswah; François Roman; Eric Stavale; Julian Wolfson; James D Neaton; H Clifford Lane
Journal:  N Engl J Med       Date:  2017-10-12       Impact factor: 91.245

6.  Social pathways for Ebola virus disease in rural Sierra Leone, and some implications for containment.

Authors:  Paul Richards; Joseph Amara; Mariane C Ferme; Prince Kamara; Esther Mokuwa; Amara Idara Sheriff; Roland Suluku; Maarten Voors
Journal:  PLoS Negl Trop Dis       Date:  2015-04-17

7.  An IDEA for short term outbreak projection: nearcasting using the basic reproduction number.

Authors:  David N Fisman; Tanya S Hauck; Ashleigh R Tuite; Amy L Greer
Journal:  PLoS One       Date:  2013-12-31       Impact factor: 3.240

8.  Minimally Symptomatic Infection in an Ebola 'Hotspot': A Cross-Sectional Serosurvey.

Authors:  Eugene T Richardson; J Daniel Kelly; Mohamed Bailor Barrie; Annelies W Mesman; Sahr Karku; Komba Quiwa; Regan H Marsh; Songor Koedoyoma; Fodei Daboh; Kathryn P Barron; Michael Grady; Elizabeth Tucker; Kerry L Dierberg; George W Rutherford; Michele Barry; James Holland Jones; Megan B Murray; Paul E Farmer
Journal:  PLoS Negl Trop Dis       Date:  2016-11-15

9.  After Ebola in West Africa--Unpredictable Risks, Preventable Epidemics.

Authors:  Junerlyn Agua-Agum; Benedetta Allegranzi; Archchun Ariyarajah; R Bruce Aylward; Isobel M Blake; Philippe Barboza; Daniel Bausch; Richard J Brennan; Peter Clement; Pasqualina Coffey; Anne Cori; Christl A Donnelly; Ilaria Dorigatti; Patrick Drury; Kara Durski; Christopher Dye; Tim Eckmanns; Neil M Ferguson; Christophe Fraser; Erika Garcia; Tini Garske; Alex Gasasira; Céline Gurry; Esther Hamblion; Wes Hinsley; Robert Holden; David Holmes; Stéphane Hugonnet; Giovanna Jaramillo Gutierrez; Thibaut Jombart; Edward Kelley; Ravi Santhana; Nuha Mahmoud; Harriet L Mills; Yasmine Mohamed; Emmanuel Musa; Dhamari Naidoo; Gemma Nedjati-Gilani; Emily Newton; Ian Norton; Pierre Nouvellet; Devin Perkins; Mark Perkins; Steven Riley; Dirk Schumacher; Anita Shah; Minh Tang; Olivia Varsaneux; Maria D Van Kerkhove
Journal:  N Engl J Med       Date:  2016-08-11       Impact factor: 91.245

Review 10.  Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis.

Authors:  Julii Brainard; Lee Hooper; Katherine Pond; Kelly Edmunds; Paul R Hunter
Journal:  Int J Epidemiol       Date:  2015-11-20       Impact factor: 7.196
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  9 in total

1.  Frontier review on the propensity and repercussion of SARS-CoV-2 migration to aquatic environment.

Authors:  Manish Kumar; Alok Kumar Thakur; Payal Mazumder; Keisuke Kuroda; Sanjeeb Mohapatra; Jörg Rinklebe; Al Ramanathan; Zeynep Cetecioglu; Sharad Jain; Vinay Kumar Tyagi; Petros Gikas; Sudip Chakraborty; M Tahmidul Islam; Arslan Ahmad; Anil V Shah; Arbind Kumar Patel; Toru Watanabe; Meththika Vithanage; Kyle Bibby; Masaaki Kitajima; Prosun Bhattacharya
Journal:  J Hazard Mater Lett       Date:  2020-08-31

2.  Food Insecurity as a Risk Factor for Outcomes Related to Ebola Virus Disease in Kono District, Sierra Leone: A Cross-Sectional Study.

Authors:  J Daniel Kelly; Eugene T Richardson; Michael Drasher; M Bailor Barrie; Sahr Karku; Mohamed Kamara; Katrina Hann; Kerry Dierberg; Allan Hubbard; Christina P Lindan; Paul E Farmer; George W Rutherford; Sheri D Weiser
Journal:  Am J Trop Med Hyg       Date:  2018-03-15       Impact factor: 2.345

3.  Reporting quality of the 2014 Ebola outbreak in Africa: A systematic analysis.

Authors:  Nina Huynh; Andrea Baumann; Mark Loeb
Journal:  PLoS One       Date:  2019-06-25       Impact factor: 3.240

4.  Projections of Ebola outbreak size and duration with and without vaccine use in Équateur, Democratic Republic of Congo, as of May 27, 2018.

Authors:  J Daniel Kelly; Lee Worden; S Rae Wannier; Nicole A Hoff; Patrick Mukadi; Cyrus Sinai; Sarah Ackley; Xianyun Chen; Daozhou Gao; Bernice Selo; Mathais Mossoko; Emile Okitolonda-Wemakoy; Eugene T Richardson; George W Rutherford; Thomas M Lietman; Jean Jacques Muyembe-Tamfum; Anne W Rimoin; Travis C Porco
Journal:  PLoS One       Date:  2019-03-07       Impact factor: 3.240

5.  The Impact of Different Types of Violence on Ebola Virus Transmission During the 2018-2020 Outbreak in the Democratic Republic of the Congo.

Authors:  John Daniel Kelly; Sarah Rae Wannier; Cyrus Sinai; Caitlin A Moe; Nicole A Hoff; Seth Blumberg; Bernice Selo; Mathais Mossoko; Gerardo Chowell-Puente; James Holland Jones; Emile Okitolonda-Wemakoy; George W Rutherford; Thomas M Lietman; Jean Jacques Muyembe-Tamfum; Anne W Rimoin; Travis C Porco; Eugene T Richardson
Journal:  J Infect Dis       Date:  2020-11-13       Impact factor: 5.226

6.  SARS-CoV-2 antibody prevalence in Sierra Leone, March 2021: a cross-sectional, nationally representative, age-stratified serosurvey.

Authors:  Mohamed Bailor Barrie; Sulaiman Lakoh; J Daniel Kelly; Joseph Sam Kanu; James Sylvester Squire; Zikan Koroma; Silleh Bah; Osman Sankoh; Abdulai Brima; Rashid Ansumana; Sarah A Goldberg; Smit Chitre; Chidinma Osuagwu; Raphael Frankfurter; Justin Maeda; Bernard Barekye; Tamuno-Wari Numbere; Mohammed Abdulaziz; Anthony Mounts; Curtis Blanton; Tushar Singh; Mohamed Samai; Mohamed Vandi; Eugene T Richardson
Journal:  BMJ Glob Health       Date:  2021-11

7.  Association of Lower Exposure Risk With Paucisymptomatic/Asymptomatic Infection, Less Severe Disease, and Unrecognized Ebola Virus Disease: A Seroepidemiological Study.

Authors:  J Daniel Kelly; Raphael G Frankfurter; Jacqueline M Tavs; Mohamed Bailor Barrie; Timothy McGinnis; Mohamed Kamara; Adams Freeman; Komba Quiwah; Michelle C Davidson; Bonnie Dighero-Kemp; Harrison Gichini; Elizabeth Elliott; Cavan Reilly; Lisa E Hensley; H Clifford Lane; Sheri D Weiser; Travis C Porco; George W Rutherford; Eugene T Richardson
Journal:  Open Forum Infect Dis       Date:  2022-03-07       Impact factor: 4.423

8.  SARS-CoV-2 antibody prevalence in Sierra Leone, March 2021: a cross-sectional, nationally representative, age-stratified serosurvey.

Authors:  Mohamed Bailor Barrie; Sulaiman Lakoh; J Daniel Kelly; Joseph Sam Kanu; James Squire; Zikan Koroma; Silleh Bah; Osman Sankoh; Abdulai Brima; Rashid Ansumana; Sarah A Goldberg; Smit Chitre; Chidinma Osuagwu; Justin Maeda; Bernard Barekye; Tamuno-Wari Numbere; Mohammed Abdulaziz; Anthony Mounts; Curtis Blanton; Tushar Singh; Mohamed Samai; Mohamed A Vandi; Eugene T Richardson
Journal:  medRxiv       Date:  2021-07-05

9.  Early transmission and case fatality of Ebola virus at the index site of the 2013-16 west African Ebola outbreak: a cross-sectional seroprevalence survey.

Authors:  Joseph W S Timothy; Yper Hall; Joseph Akoi-Boré; Boubacar Diallo; Thomas R W Tipton; Hilary Bower; Thomas Strecker; Judith R Glynn; Miles W Carroll
Journal:  Lancet Infect Dis       Date:  2019-02-21       Impact factor: 25.071
  9 in total

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