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Literature DB >> 29321181

Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond.

Emery H Bresnick¹, Kyle J Hewitt², Charu Mehta², Sunduz Keles³, Robert F Paulson⁴, Kirby D Johnson².

Abstract

Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital requirement for oxygen to support metabolically active cells and tissues is well established, almost nothing is known regarding how erythrocyte development and function impact regeneration. Furthermore, many questions remain unanswered relating to how insults to hematopoietic stem/progenitor cells and erythrocytes can trigger a massive regenerative process termed 'stress erythropoiesis' to produce billions of erythrocytes. Here, we review the cellular and molecular mechanisms governing erythrocyte development and regeneration, and discuss the potential links between these events and other regenerative processes.

Entities: Chemical

Keywords: Erythroblast; Erythrocyte; Regeneration; Stress; Transcription

Mesh：

Substances：
Oxygen

Year: 2018 PMID： 29321181 PMCID： PMC5825862 DOI： 10.1242/dev.151423

Source DB: PubMed Journal: Development ISSN： 0950-1991 Impact factor: 6.868

215 in total

1. Autophagy driven by a master regulator of hematopoiesis.

Authors: Yoon-A Kang; Rajendran Sanalkumar; Henriette O'Geen; Amelia K Linnemann; Chan-Jung Chang; Eric E Bouhassira; Peggy J Farnham; Sunduz Keles; Emery H Bresnick
Journal: Mol Cell Biol Date: 2011-10-24 Impact factor: 4.272

2. Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei.

Authors: Laura Lahti; Maarja Haugas; Laura Tikker; Mikko Airavaara; Merja H Voutilainen; Jenni Anttila; Suman Kumar; Caisa Inkinen; Marjo Salminen; Juha Partanen
Journal: Development Date: 2015-12-30 Impact factor: 6.868

3. A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation.

Authors: Valentina Poletto; Vittorio Rosti; Laura Villani; Paolo Catarsi; Adriana Carolei; Rita Campanelli; Margherita Massa; Myriam Martinetti; Gianluca Viarengo; Alberto Malovini; Anna Rita Migliaccio; Giovanni Barosi
Journal: Blood Date: 2012-08-09 Impact factor: 22.113

4. Differentiation of human embryonic stem cells to HOXA⁺ hemogenic vasculature that resembles the aorta-gonad-mesonephros.

Authors: Elizabeth S Ng; Lisa Azzola; Freya F Bruveris; Vincenzo Calvanese; Belinda Phipson; Katerina Vlahos; Claire Hirst; Vanta J Jokubaitis; Qing C Yu; Jovana Maksimovic; Simone Liebscher; Vania Januar; Zhen Zhang; Brenda Williams; Aude Conscience; Jennifer Durnall; Steven Jackson; Magdaline Costa; David Elliott; David N Haylock; Susan K Nilsson; Richard Saffery; Katja Schenke-Layland; Alicia Oshlack; Hanna K A Mikkola; Edouard G Stanley; Andrew G Elefanty
Journal: Nat Biotechnol Date: 2016-10-17 Impact factor: 54.908

5. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

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Journal: Nature Date: 1999-05-20 Impact factor: 49.962

6. Genetic framework for GATA factor function in vascular biology.

Authors: Amelia K Linnemann; Henriette O'Geen; Sunduz Keles; Peggy J Farnham; Emery H Bresnick
Journal: Proc Natl Acad Sci U S A Date: 2011-08-01 Impact factor: 11.205

7. Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia.

Authors: Alyssa Carey; David K Edwards; Christopher A Eide; Laura Newell; Elie Traer; Bruno C Medeiros; Daniel A Pollyea; Michael W Deininger; Robert H Collins; Jeffrey W Tyner; Brian J Druker; Grover C Bagby; Shannon K McWeeney; Anupriya Agarwal
Journal: Cell Rep Date: 2017-03-28 Impact factor: 9.423

8. The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors.

Authors: Abeer El Wakil; Cédric Francius; Annie Wolff; Jocelyne Pleau-Varet; Jeannette Nardelli
Journal: Development Date: 2006-05-03 Impact factor: 6.868

9. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression.

Authors: Bing-Mei Zhu; Sara K McLaughlin; Risu Na; Jie Liu; Yongzhi Cui; Cyril Martin; Akiko Kimura; Gertraud W Robinson; Nancy C Andrews; Lothar Hennighausen
Journal: Blood Date: 2008-06-13 Impact factor: 22.113

10. Development of hematopoietic stem cell activity in the mouse embryo.

Authors: A M Müller; A Medvinsky; J Strouboulis; F Grosveld; E Dzierzak
Journal: Immunity Date: 1994-07 Impact factor: 31.745

19 in total

1. Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation.

Authors: Yuanting Chen; Jie Xiang; Fenghua Qian; Bastihalli T Diwakar; Baiye Ruan; Siyang Hao; K Sandeep Prabhu; Robert F Paulson
Journal: Blood Date: 2020-07-09 Impact factor: 22.113

Review 2. Blood disease-causing and -suppressing transcriptional enhancers: general principles and GATA2 mechanisms.

Authors: Emery H Bresnick; Kirby D Johnson
Journal: Blood Adv Date: 2019-07-09

3. Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.

Authors: Carmen G Palii; Qian Cheng; Mark A Gillespie; Paul Shannon; Michalina Mazurczyk; Giorgio Napolitani; Nathan D Price; Jeffrey A Ranish; Edward Morrissey; Douglas R Higgs; Marjorie Brand
Journal: Cell Stem Cell Date: 2019-03-14 Impact factor: 24.633

Review 4. Regeneration enhancers: Starting a journey to unravel regulatory events in tissue regeneration.

Authors: Anjelica M Rodriguez; Junsu Kang
Journal: Semin Cell Dev Biol Date: 2019-04-08 Impact factor: 7.727

5. Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita.

Authors: Wilson Chun Fok; Siddharth Shukla; Alexandre Teixeira Vessoni; Kirsten Ann Brenner; Roy Parker; Christopher M Sturgeon; Luis Francisco Zirnberger Batista
Journal: Blood Date: 2019-02-06 Impact factor: 22.113