PURPOSE: Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and non-overweight controls. MATERIALS AND METHODS: The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. CONCLUSIONS: The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.
PURPOSE: Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and non-overweight controls. MATERIALS AND METHODS: The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. CONCLUSIONS: The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.
Authors: Anders Gummesson; Daniel Hagg; Fredrik J Olson; Johannes Hulthe; Lena M S Carlsson; Bjorn Fagerberg Journal: Scand J Clin Lab Invest Date: 2009 Impact factor: 1.713
Authors: J R Salameh; Ladawn M Talbott; Warren May; Bashar Gosheh; Parminder J S Vig; D Olga McDaniel Journal: Am Surg Date: 2007-06 Impact factor: 0.688
Authors: José María Moreno-Navarrete; Victoria Catalán; Lauren Whyte; Adenis Díaz-Arteaga; Rafael Vázquez-Martínez; Fernando Rotellar; Rocío Guzmán; Javier Gómez-Ambrosi; Marina R Pulido; Wendy R Russell; Mónica Imbernón; Ruth A Ross; María M Malagón; Carlos Dieguez; José Manuel Fernández-Real; Gema Frühbeck; Ruben Nogueiras Journal: Diabetes Date: 2011-12-16 Impact factor: 9.461