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Literature DB >> 29296992

Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Nishad Thamban Chandrika¹, Sylvie Garneau-Tsodikova.

Abstract

A systematic analysis of all synthetic and chemoenzymatic methodologies for the preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) reported in the scientific literature up to 2017 is presented. This comprehensive analysis of derivatization/generation of novel aminoglycosides and their conjugates is divided based on the types of modifications used to make the new derivatives. Both the chemical strategies utilized and the biological results observed are covered. Structure-activity relationships based on different synthetic modifications along with their implications for activity and ability to avoid resistance against different microorganisms are also presented.

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Year: 2018 PMID： 29296992 PMCID： PMC5818290 DOI： 10.1039/c7cs00407a

Source DB: PubMed Journal: Chem Soc Rev ISSN： 0306-0012 Impact factor: 54.564

290 in total

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