| Literature DB >> 15993084 |
Mariana Hainrichson1, Varvara Pokrovskaya, Dalia Shallom-Shezifi, Micha Fridman, Valery Belakhov, Dina Shachar, Sima Yaron, Timor Baasov.
Abstract
The C5''-OH group in neomycin B was glycosylated with a variety of mono- and di-saccharides to probe the effect of introduction of additional binding elements on antibacterial activity and interaction with the aminoglycosides modifying enzyme APH(3')-IIIa. The designed structures show antibacterial activity superior to that of neomycin B against pathogenic and resistant strains, while in parallel they demonstrate poor substrate activity with APH(3')-IIIa.Entities:
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Year: 2005 PMID： 15993084 DOI： 10.1016/j.bmc.2005.05.058
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641