Literature DB >> 21537023

Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.

Keith D Green1, Wenjing Chen, Sylvie Garneau-Tsodikova.   

Abstract

Aminoglycoside-modifying enzymes (AMEs) constitute the most prevalent mechanism of resistance to aminoglycosides by bacteria. We show that aminoglycosides can be doubly modified by the sequential actions of AMEs, with the activity of the second AME in most cases unaffected, decreased, or completely abolished. We demonstrate that the bifunctional enzyme AAC(3)-Ib/AAC(6')-Ib' can diacetylate gentamicin. Since single acetylation does not always inactivate the parent drugs completely, two modifications likely provide more-robust inactivation in vivo.

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Year:  2011        PMID： 21537023      PMCID： PMC3122451          DOI： 10.1128/AAC.00312-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  32 in total

1.  The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance.

Authors:  Didier Nurizzo; Steven C Shewry; Michael H Perlin; Scott A Brown; Jaydev N Dholakia; Roy L Fuchs; Taru Deva; Edward N Baker; Clyde A Smith
Journal:  J Mol Biol       Date:  2003-03-21       Impact factor: 5.469

2.  Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates.

Authors:  Matthew W Vetting; Subray S Hegde; Farah Javid-Majd; John S Blanchard; Steven L Roderick
Journal:  Nat Struct Biol       Date:  2002-09

3.  Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2'').

Authors:  David D Boehr; Denis M Daigle; Gerard D Wright
Journal:  Biochemistry       Date:  2004-08-03       Impact factor: 3.162

4.  Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase.

Authors:  E Wolf; A Vassilev; Y Makino; A Sali; Y Nakatani; S K Burley
Journal:  Cell       Date:  1998-08-21       Impact factor: 41.582

5.  Assessment of 6'- and 6'''-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance.

Authors:  Pazit Shaul; Keith D Green; Roi Rutenberg; Maria Kramer; Yifat Berkov-Zrihen; Elinor Breiner-Goldstein; Sylvie Garneau-Tsodikova; Micha Fridman
Journal:  Org Biomol Chem       Date:  2011-03-01       Impact factor: 3.876

6.  Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3')-IIIa).

Authors:  P R Thompson; D W Hughes; G D Wright
Journal:  Biochemistry       Date:  1996-07-02       Impact factor: 3.162

7.  Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold.

Authors:  L E Wybenga-Groot; K Draker; G D Wright; A M Berghuis
Journal:  Structure       Date:  1999-05       Impact factor: 5.006

8.  Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci.

Authors:  D M Daigle; D W Hughes; G D Wright
Journal:  Chem Biol       Date:  1999-02

9.  Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase.

Authors:  L C Pedersen; M M Benning; H M Holden
Journal:  Biochemistry       Date:  1995-10-17       Impact factor: 3.162

10.  A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones.

Authors:  Matthew W Vetting; Sophie Magnet; Edward Nieves; Steven L Roderick; John S Blanchard
Journal:  Chem Biol       Date:  2004-04
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  28 in total

1.  Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure.

Authors:  Shane J Caldwell; Albert M Berghuis
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

2.  6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes.

Authors:  Ido M Herzog; Keith D Green; Yifat Berkov-Zrihen; Mark Feldman; Roee R Vidavski; Anat Eldar-Boock; Ronit Satchi-Fainaro; Avigdor Eldar; Sylvie Garneau-Tsodikova; Micha Fridman
Journal:  Angew Chem Int Ed Engl       Date:  2012-04-12       Impact factor: 15.336

3.  Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone-Neomycin Conjugates.

Authors:  Natalya N Degtyareva; Changjun Gong; Sandra Story; Nathanael S Levinson; Adegboyega K Oyelere; Keith D Green; Sylvie Garneau-Tsodikova; Dev P Arya
Journal:  ACS Infect Dis       Date:  2017-02-17       Impact factor: 5.084

4.  Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents.

Authors:  Sanjib K Shrestha; Marina Y Fosso; Keith D Green; Sylvie Garneau-Tsodikova
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

5.  Tobramycin Variants with Enhanced Ribosome-Targeting Activity.

Authors:  Marina Y Fosso; Hongkun Zhu; Keith D Green; Sylvie Garneau-Tsodikova; Kurt Fredrick
Journal:  Chembiochem       Date:  2015-06-17       Impact factor: 3.164

6.  A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Medchemcomm       Date:  2015-11-19       Impact factor: 3.597

7.  Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum β-Lactamases Collected in Two Multicenter Studies in Spain.

Authors:  Marta Fernández-Martínez; Belén Ruiz Del Castillo; Maria Jesús Lecea-Cuello; Jesús Rodríguez-Baño; Álvaro Pascual; Luis Martínez-Martínez
Journal:  Microb Drug Resist       Date:  2017-10-03       Impact factor: 3.431

8.  Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria.

Authors:  Keith D Green; Rachel E Pricer; Megan N Stewart; Sylvie Garneau-Tsodikova
Journal:  ACS Infect Dis       Date:  2015-05-04       Impact factor: 5.084

9.  Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.

Authors:  Nishad Thamban Chandrika; Keith D Green; Jacob L Houghton; Sylvie Garneau-Tsodikova
Journal:  ACS Med Chem Lett       Date:  2015-09-30       Impact factor: 4.345

10.  Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens.

Authors:  Keith D Green; Sylvie Garneau-Tsodikova
Journal:  Biochimie       Date:  2013-02-26       Impact factor: 4.079
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