Literature DB >> 29259862

Disseminated mucormycosis: A sinister cause of neutropenic fever syndrome.

Ghazal Tansir1, Neha Rastogi2, Prashant Ramteke3, Prabhat Kumar1, Manish Soneja1, Ashutosh Biswas1, Sanchit Kumar1, Pankaj Jorwal1, Upendra Baitha1.   

Abstract

A 15 year old girl presented with complaints of prolonged fever and recurrent episodes of hemoptysis. Initial investigation showed pancytopenia and radiological imaging was suggestive of necrotizing pneumonia. Subsequently, mucor was isolated from bronchoalveolar lavage fluid, but even on appropriate medications her condition kept deteriorating. She had multiple bouts of hemoptysis and a repeat imaging of chest showed dissemination of mucormycosis to pulmonary vein and heart. Bone marrow biopsy identified acute lymphoblastic leukemia (ALL) as the cause of pancytopenia. She was planned for bronchial artery embolization and chemotherapy for ALL, but consent was not given and she left our institute against medical advice. Our case highlights the importance of keeping a high index of suspicion for disseminated mucormycosis in neutropenic patients, as any delay in diagnosis and treatment could have grave consequences.

Entities:  

Keywords:  Cardiac mucormycosis; acute lymphoblastic leukemia; galactomannan

Year:  2017        PMID: 29259862      PMCID: PMC5735287          DOI: 10.5582/irdr.2017.01063

Source DB:  PubMed          Journal:  Intractable Rare Dis Res        ISSN: 2186-3644


  17 in total

Review 1.  Febrile neutropenia in hematologic malignancies.

Authors:  Michael K Keng; Mikkael A Sekeres
Journal:  Curr Hematol Malig Rep       Date:  2013-12       Impact factor: 3.952

Review 2.  Why is mucormycosis more difficult to cure than more common mycoses?

Authors:  A Katragkou; T J Walsh; E Roilides
Journal:  Clin Microbiol Infect       Date:  2014-01-28       Impact factor: 8.067

3.  Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: a prospective observational study.

Authors:  L Y Hsu; D G Lee; S P Yeh; D Bhurani; B Q Khanh; C Y Low; L Norasetthada; T Chan; Y L Kwong; A K Vaid; I Alejandria; M Mendoza; C Y Chen; A Johnson; T Y Tan
Journal:  Clin Microbiol Infect       Date:  2015-03-05       Impact factor: 8.067

4.  Zygomycosis in the 1990s in a tertiary-care cancer center.

Authors:  D P Kontoyiannis; V C Wessel; G P Bodey; K V Rolston
Journal:  Clin Infect Dis       Date:  2000-06-13       Impact factor: 9.079

Review 5.  The clinical manifestations of cardiac mucormycosis.

Authors:  J D Jackman; R L Simonsen
Journal:  Chest       Date:  1992-06       Impact factor: 9.410

6.  Invasive zygomycosis in India: experience in a tertiary care hospital.

Authors:  A Chakrabarti; S S Chatterjee; A Das; N Panda; M R Shivaprakash; A Kaur; S C Varma; S Singhi; A Bhansali; V Sakhuja
Journal:  Postgrad Med J       Date:  2009-11       Impact factor: 2.401

7.  Cardiac fungal infections: review of autopsy findings in 60 patients.

Authors:  J B Atkinson; D H Connor; M Robinowitz; H A McAllister; R Virmani
Journal:  Hum Pathol       Date:  1984-10       Impact factor: 3.466

8.  Successful treatment of mucormycosis endocarditis complicated by pulmonary involvement.

Authors:  N Gubarev; J Separovic; V Gasparovic; I Jelic
Journal:  Thorac Cardiovasc Surg       Date:  2007-06       Impact factor: 1.827

9.  Epidemiology and clinical manifestation of fungal infection related to Mucormycosis in hematologic malignancies.

Authors:  M Noorifard; E Sekhavati; H Jalaei Khoo; I Hazraty; R Tabrizi
Journal:  J Med Life       Date:  2015

10.  Pulmonary mucormycosis: an emerging infection.

Authors:  Mohammed Muqeetadnan; Ambreen Rahman; Syed Amer; Salman Nusrat; Syed Hassan; Syed Hashmi
Journal:  Case Rep Pulmonol       Date:  2012-12-12
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  1 in total

1.  Case of mucormycosis of mandible after self-extraction of teeth incidentally detected to have chronic granulomatous disease: Case report and literature review.

Authors:  Shubham Agarwal; Abhishek Anand; Piyush Ranjan; Ved Prakash Meena; Animesh Ray; Rimlee Dutta; Ranveer Singh Jadon; Naval Kishore Vikram
Journal:  Med Mycol Case Rep       Date:  2020-04-11
  1 in total

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