| Literature DB >> 25749561 |
L Y Hsu1, D G Lee2, S P Yeh3, D Bhurani4, B Q Khanh5, C Y Low6, L Norasetthada7, T Chan8, Y L Kwong8, A K Vaid9, I Alejandria10, M Mendoza10, C Y Chen11, A Johnson12, T Y Tan13.
Abstract
We conducted a 2-year multicentre prospective observational study to determine the epidemiology of and mortality associated with invasive fungal diseases (IFDs) among patients with haematological disorders in Asia. Eleven institutions from 8 countries/regions participated, with 412 subjects (28.2% possible, 38.3% probable and 33.5% proven IFDs) recruited. The epidemiology of IFDs in participating institutions was similar to Western centres, with Aspergillus spp. (65.9%) or Candida spp. (26.7%) causing the majority of probable and proven IFDs. The overall 30-day mortality was 22.1%. Progressive haematological disorder (odds ratio [OR] 5.192), invasive candidiasis (OR 3.679), and chronic renal disease (OR 6.677) were independently associated with mortality.Entities:
Keywords: Antifungal agents; Asia-Pacific; epidemiology; haematological diseases; invasive fungal disease
Mesh：
Year: 2015 PMID： 25749561 DOI： 10.1016/j.cmi.2015.02.019
Source DB: PubMed Journal: Clin Microbiol Infect ISSN： 1198-743X Impact factor: 8.067