| Literature DB >> 29259752 |
Nada Abla1,2, Sridevi Bashyam3, Susan A Charman4, Béatrice Greco1, Philip Hewitt5, Maria Belén Jiménez-Díaz6, Kasiram Katneni4, Holger Kubas5, Didier Picard7, Yuvaraj Sambandan3, Laura Sanz6, Dennis Smith4, Tai Wang7, Paul Willis2, Sergio Wittlin8,9, Thomas Spangenberg1.
Abstract
With ∼429,000 deaths in 2016, malaria remains a major infectious disease where the need to treat the fever symptoms, but also to provide relevant post-treatment prophylaxis, is of major importance. An azepanylcarbazole amino alcohol is disclosed with a long- and fast-acting in vivo antiplasmodial efficacy and meets numerous attributes of a desired post-treatment chemoprophylactic antimalarial agent. The synthesis, the parasitological characterization, and the animal pharmacokinetics and pharmacodynamics of this compound are presented along with a proposed target.Entities:
Year: 2017 PMID： 29259752 PMCID： PMC5733276 DOI： 10.1021/acsmedchemlett.7b00391
Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345