| Literature DB >> 9491767 |
G Bringmann1, A Ledermann, J Holenz, M T Kao, U Busse, H G Wu, G François.
Abstract
A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).Entities:
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Year: 1998 PMID： 9491767 DOI： 10.1055/s-2006-957366
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352