| Literature DB >> 18691886 |
Jason D Hughes1, Julian Blagg, David A Price, Simon Bailey, Gary A Decrescenzo, Rajesh V Devraj, Edmund Ellsworth, Yvette M Fobian, Michael E Gibbs, Richard W Gilles, Nigel Greene, Enoch Huang, Teresa Krieger-Burke, Jens Loesel, Travis Wager, Larry Whiteley, Yao Zhang.
Abstract
Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.Entities:
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Year: 2008 PMID： 18691886 DOI： 10.1016/j.bmcl.2008.07.071
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823