Humans as a model for understanding biological fundamentals.

How special are humans? This question drives scholarly output across both the sciences and the humanities. Whereas some disciplines, and the humanities in particular, aim at gaining a better understanding of humans per se, most biologists ultimately aim to understand life in general. This raises the question of whether and when humans are acceptable, or even desirable, models of biological fundamentals. Especially for basic biological processes, non-human species are generally accepted as a relevant model to study topics for which studying humans is impractical, impossible, or ethically inadvisable, but the reverse is controversial: are humans 'too unique' to be informative with respect to biological fundamentals relevant to other species? Or are there areas where we share key components, or for which our very uniqueness serves to allow novel explorations? In this special feature, authors from disciplines including biology, psychology, anthropology, neuroscience and philosophy tackle this question. Their overall conclusion is a qualified yes: humans do tell us about biological fundamentals, in some contexts. We hope this special feature will spur a discussion that will lead to a more careful delineation of the similarities and the differences between humans and other species, and how these impact the study of biological fundamentals.