Literature DB >> 29217119

Panomics for Precision Medicine.

Charanjit Sandhu1, Alia Qureshi2, Andrew Emili3.   

Abstract

Medicine is poised to undergo a digital transformation. High-throughput platforms are creating terabytes of genomic, transcriptomic, proteomic, and metabolomic data. The challenge is to interpret these data in a meaningful manner - to uncover relationships that are not readily apparent between molecular profiles and states of health or disease. This will require the development of novel data pipelines and computational tools. The combined analysis of multi-dimensional data is referred to as 'panomics'. The ultimate hope of integrative panomics is that it will lead to the discovery and application of novel markers and targeted therapeutics that drive forward a new era of 'precision medicine' where inter-individual variation is accounted for in the treatment of patients.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  genomics; metabolomics; panomics; precision medicine; proteomics; transcriptomics

Mesh:

Year:  2017        PMID: 29217119      PMCID: PMC5839674          DOI: 10.1016/j.molmed.2017.11.001

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN: 1471-4914            Impact factor:   15.272


  114 in total

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Authors:  Miguel Á Martínez-González; Miguel Ruiz-Canela; Adela Hruby; Liming Liang; Antonia Trichopoulou; Frank B Hu
Journal:  J Nutr       Date:  2015-04-01       Impact factor: 4.798

Review 2.  Mapping the human toxome by systems toxicology.

Authors:  Mounir Bouhifd; Helena T Hogberg; Andre Kleensang; Alexandra Maertens; Liang Zhao; Thomas Hartung
Journal:  Basic Clin Pharmacol Toxicol       Date:  2014-02-15       Impact factor: 4.080

3.  Mass spectrometry in untargeted liquid chromatography/mass spectrometry metabolomics: Electrospray ionisation parameters and global coverage of the metabolome.

Authors:  Fidele Tugizimana; Paul A Steenkamp; Lizelle A Piater; Ian A Dubery
Journal:  Rapid Commun Mass Spectrom       Date:  2018-01-30       Impact factor: 2.419

4.  Discovery of gastric cancer specific biomarkers by the application of serum proteomics.

Authors:  Moon-Won Yoo; Jisook Park; Hye-Seung Han; Yeo-Min Yun; Jeong Won Kang; Do-Young Choi; Joon Won Lee; Jae Hun Jung; Kyung-Yung Lee; Kwang Pyo Kim
Journal:  Proteomics       Date:  2017-03       Impact factor: 3.984

Review 5.  Epidermal growth factor receptor targeting in cancer: a review of trends and strategies.

Authors:  Chetan Yewale; Dipesh Baradia; Imran Vhora; Sushilkumar Patil; Ambikanandan Misra
Journal:  Biomaterials       Date:  2013-08-13       Impact factor: 12.479

6.  Circulating microRNAs in the cerebrospinal fluid of patients with brain diseases.

Authors:  Akira Machida; Takuya Ohkubo; Takanori Yokota
Journal:  Methods Mol Biol       Date:  2013

Review 7.  Personalized treatment options for ALK-positive metastatic non-small-cell lung cancer: potential role for Ceritinib.

Authors:  Hazem El-Osta; Rodney Shackelford
Journal:  Pharmgenomics Pers Med       Date:  2015-09-29

8.  Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease.

Authors:  Xiaowen Zheng; Feng Chen; Qian Zhang; Yulan Liu; Peng You; Shan Sun; Jiuxiang Lin; Ning Chen
Journal:  Protein Cell       Date:  2017-05-18       Impact factor: 14.870

Review 9.  Extracellular microRNAs in urologic malignancies: chances and challenges.

Authors:  Xiaoyi Huang; Meihua Liang; Rachel Dittmar; Liang Wang
Journal:  Int J Mol Sci       Date:  2013-07-16       Impact factor: 5.923

10.  Landscape of transcription in human cells.

Authors:  Sarah Djebali; Carrie A Davis; Angelika Merkel; Alex Dobin; Timo Lassmann; Ali Mortazavi; Andrea Tanzer; Julien Lagarde; Wei Lin; Felix Schlesinger; Chenghai Xue; Georgi K Marinov; Jainab Khatun; Brian A Williams; Chris Zaleski; Joel Rozowsky; Maik Röder; Felix Kokocinski; Rehab F Abdelhamid; Tyler Alioto; Igor Antoshechkin; Michael T Baer; Nadav S Bar; Philippe Batut; Kimberly Bell; Ian Bell; Sudipto Chakrabortty; Xian Chen; Jacqueline Chrast; Joao Curado; Thomas Derrien; Jorg Drenkow; Erica Dumais; Jacqueline Dumais; Radha Duttagupta; Emilie Falconnet; Meagan Fastuca; Kata Fejes-Toth; Pedro Ferreira; Sylvain Foissac; Melissa J Fullwood; Hui Gao; David Gonzalez; Assaf Gordon; Harsha Gunawardena; Cedric Howald; Sonali Jha; Rory Johnson; Philipp Kapranov; Brandon King; Colin Kingswood; Oscar J Luo; Eddie Park; Kimberly Persaud; Jonathan B Preall; Paolo Ribeca; Brian Risk; Daniel Robyr; Michael Sammeth; Lorian Schaffer; Lei-Hoon See; Atif Shahab; Jorgen Skancke; Ana Maria Suzuki; Hazuki Takahashi; Hagen Tilgner; Diane Trout; Nathalie Walters; Huaien Wang; John Wrobel; Yanbao Yu; Xiaoan Ruan; Yoshihide Hayashizaki; Jennifer Harrow; Mark Gerstein; Tim Hubbard; Alexandre Reymond; Stylianos E Antonarakis; Gregory Hannon; Morgan C Giddings; Yijun Ruan; Barbara Wold; Piero Carninci; Roderic Guigó; Thomas R Gingeras
Journal:  Nature       Date:  2012-09-06       Impact factor: 49.962

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  23 in total

1.  Serum exosome-derived biomarkers for the early detection of oral squamous cell carcinoma.

Authors:  Hejia Guo; Weidong Jiang; Suhua Huang; Xuanping Huang; Cuiping Li
Journal:  Mol Cell Biochem       Date:  2021-09-01       Impact factor: 3.396

2.  Precision Medicine and the Practice of Trichiatry: Adapting the Concept.

Authors:  Ralph M Trüeb; Vicky M L Jolliffe; Antonia Fellas Régnier; Hudson Dutra Rezende; Sergio Vañó-Galván; Daisy Kopera; Demetrios Ioannides; Maria Fernanda Reis Gavazzoni Dias; Melanie Macpherson; Aida Gadzhigoroeva; Julya Ovcharenko; Won-Soo Lee; Sundaram Murugusundram; Sotaro Kurata; Mimi Chang; Chuchai Tanglertsampan
Journal:  Skin Appendage Disord       Date:  2019-08-20

3.  The San Diego Nathan Shock Center: tackling the heterogeneity of aging.

Authors:  Gerald S Shadel; Peter D Adams; W Travis Berggren; Jolene K Diedrich; Kenneth E Diffenderfer; Fred H Gage; Nasun Hah; Malene Hansen; Martin W Hetzer; Anthony J A Molina; Uri Manor; Kurt Marek; David D O'Keefe; Antonio F M Pinto; Alessandra Sacco; Tatyana O Sharpee; Maxim N Shokriev; Stefania Zambetti
Journal:  Geroscience       Date:  2021-08-09       Impact factor: 7.713

Review 4.  Pro-biomics: Omics Technologies To Unravel the Role of Probiotics in Health and Disease.

Authors:  Despoina Eugenia Kiousi; Marina Rathosi; Margaritis Tsifintaris; Pelagia Chondrou; Alex Galanis
Journal:  Adv Nutr       Date:  2021-10-01       Impact factor: 8.701

5.  Utilizing graph machine learning within drug discovery and development.

Authors:  Thomas Gaudelet; Ben Day; Arian R Jamasb; Jyothish Soman; Cristian Regep; Gertrude Liu; Jeremy B R Hayter; Richard Vickers; Charles Roberts; Jian Tang; David Roblin; Tom L Blundell; Michael M Bronstein; Jake P Taylor-King
Journal:  Brief Bioinform       Date:  2021-11-05       Impact factor: 11.622

Review 6.  Using stratified medicine to understand, diagnose, and treat neuropathic pain.

Authors:  Andreas C Themistocleous; Geert Crombez; Georgios Baskozos; David L Bennett
Journal:  Pain       Date:  2018-09       Impact factor: 7.926

7.  The High-Throughput Analyses Era: Are We Ready for the Data Struggle?

Authors:  Valeria D'Argenio
Journal:  High Throughput       Date:  2018-03-02

Review 8.  The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility.

Authors:  Christian Bime; Sara M Camp; Nancy Casanova; Radu C Oita; Juliet Ndukum; Heather Lynn; Joe G N Garcia
Journal:  Transl Res       Date:  2020-06-26       Impact factor: 7.012

Review 9.  "Right-to-Try" experimental drugs: an overview.

Authors:  Vijay Mahant
Journal:  J Transl Med       Date:  2020-06-23       Impact factor: 5.531

Review 10.  Applications of RNA Indexes for Precision Oncology in Breast Cancer.

Authors:  Liming Ma; Zirui Liang; Hui Zhou; Lianghu Qu
Journal:  Genomics Proteomics Bioinformatics       Date:  2018-05-09       Impact factor: 7.691

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