Literature DB >> 29216042

The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.

Ross A Cardarelli1, Karen Jones2, Lucie I Pisella3,4, Heike J Wobst1,5, Lisa J McWilliams6, Paul M Sharpe2, Matthew P Burnham2, David J Baker6, Ilona Chudotvorova3,4, Justine Guyot3,4, Liliya Silayeva1, Danielle H Morrow7, Niek Dekker8, Stephen Zicha5, Paul A Davies7, Jörg Holenz5, Mark E Duggan5, John Dunlop5, Robert J Mather5, Qi Wang1,5, Igor Medina3,4, Nicholas J Brandon1,5, Tarek Z Deeb1, Stephen J Moss1,7,9.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 29216042      PMCID： PMC7371006          DOI： 10.1038/nm.4442

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


× No keyword cloud information.
  20 in total

1.  Free-solution, label-free molecular interactions studied by back-scattering interferometry.

Authors:  Darryl J Bornhop; Joey C Latham; Amanda Kussrow; Dmitry A Markov; Richard D Jones; Henrik S Sørensen
Journal:  Science       Date:  2007-09-21       Impact factor: 47.728

2.  Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation.

Authors:  Joshua S Grimley; Li Li; Weina Wang; Lei Wen; Lorena S Beese; Homme W Hellinga; George J Augustine
Journal:  J Neurosci       Date:  2013-10-09       Impact factor: 6.167

3.  Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival.

Authors:  Christophe Pellegrino; Olena Gubkina; Michael Schaefer; Hélène Becq; Anastasia Ludwig; Marat Mukhtarov; Ilona Chudotvorova; Severine Corby; Yuriy Salyha; Sergey Salozhin; Piotr Bregestovski; Igor Medina
Journal:  J Physiol       Date:  2011-03-21       Impact factor: 5.182

4.  Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states.

Authors:  Tarek Z Deeb; Yasuko Nakamura; Greg D Frost; Paul A Davies; Stephen J Moss
Journal:  Eur J Neurosci       Date:  2013-04-29       Impact factor: 3.386

5.  Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.

Authors:  Sudhir Sivakumaran; Ross A Cardarelli; Jamie Maguire; Matt R Kelley; Liliya Silayeva; Danielle H Morrow; Jayanta Mukherjee; Yvonne E Moore; Robert J Mather; Mark E Duggan; Nicholas J Brandon; John Dunlop; Stephen Zicha; Stephen J Moss; Tarek Z Deeb
Journal:  J Neurosci       Date:  2015-05-27       Impact factor: 6.167

6.  A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators.

Authors:  Di Zhang; Sujatha M Gopalakrishnan; Gail Freiberg; Carol S Surowy
Journal:  J Biomol Screen       Date:  2010-01-19

7.  Enhancing KCC2 function counteracts morphine-induced hyperalgesia.

Authors:  Francesco Ferrini; Louis-Etienne Lorenzo; Antoine G Godin; Miorie Le Quang; Yves De Koninck
Journal:  Sci Rep       Date:  2017-06-20       Impact factor: 4.379

8.  Improved method for efficient imaging of intracellular Cl(-) with Cl-Sensor using conventional fluorescence setup.

Authors:  Perrine Friedel; Piotr Bregestovski; Igor Medina
Journal:  Front Mol Neurosci       Date:  2013-04-10       Impact factor: 5.639

9.  Chloride extrusion enhancers as novel therapeutics for neurological diseases.

Authors:  Martin Gagnon; Marc J Bergeron; Guillaume Lavertu; Annie Castonguay; Sasmita Tripathy; Robert P Bonin; Jimena Perez-Sanchez; Dominic Boudreau; Bin Wang; Lionel Dumas; Isabelle Valade; Karine Bachand; Mariève Jacob-Wagner; Christian Tardif; Irenej Kianicka; Paul Isenring; Giorgio Attardo; Jeffrey A M Coull; Yves De Koninck
Journal:  Nat Med       Date:  2013-10-06       Impact factor: 53.440

Review 10.  Diminished KCC2 confounds synapse specificity of LTP during senescence.

Authors:  Isabella Ferando; Guido C Faas; Istvan Mody
Journal:  Nat Neurosci       Date:  2016-08-08       Impact factor: 24.884
View more
  16 in total

1.  Reply to The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.

Authors:  Martin Gagnon; Marc J Bergeron; Jimena Perez-Sanchez; Isabel Plasencia-Fernández; Louis-Etienne Lorenzo; Antoine G Godin; Annie Castonguay; Robert P Bonin; Yves De Koninck
Journal:  Nat Med       Date:  2017-12-07       Impact factor: 53.440

2.  Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model.

Authors:  Brennan J Sullivan; Pavel A Kipnis; Brandon M Carter; Li-Rong Shao; Shilpa D Kadam
Journal:  Sci Signal       Date:  2021-11-09       Impact factor: 8.192

Review 3.  Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2.

Authors:  Giorgio Belperio; Claudia Corso; Carlos B Duarte; Miranda Mele
Journal:  J Mol Neurosci       Date:  2022-07-12       Impact factor: 2.866

4.  Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.

Authors:  Kathryn L Lee; Krithika Abiraman; Christopher Lucaj; Thomas A Ollerhead; Nicholas J Brandon; Tarek Z Deeb; Jamie Maguire; Stephen J Moss
Journal:  Brain       Date:  2022-04-29       Impact factor: 15.255

Review 5.  Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability.

Authors:  Phan Q Duy; Miao He; Zhigang He; Kristopher T Kahle
Journal:  Expert Opin Ther Targets       Date:  2020-05-05       Impact factor: 6.902

6.  Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures.

Authors:  Yvonne E Moore; Tarek Z Deeb; Heramb Chadchankar; Nicholas J Brandon; Stephen J Moss
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-17       Impact factor: 11.205

Review 7.  The role of GABAergic signalling in neurodevelopmental disorders.

Authors:  Xin Tang; Rudolf Jaenisch; Mriganka Sur
Journal:  Nat Rev Neurosci       Date:  2021-03-26       Impact factor: 34.870

8.  Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury.

Authors:  Jadwiga N Bilchak; Kyle Yeakle; Guillaume Caron; Dillon Malloy; Marie-Pascale Côté
Journal:  Exp Neurol       Date:  2021-01-13       Impact factor: 5.330

Review 9.  Advances in the development of novel compounds targeting cation-chloride cotransporter physiology.

Authors:  Eric Delpire
Journal:  Am J Physiol Cell Physiol       Date:  2020-12-23       Impact factor: 5.282

10.  Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders.

Authors:  Annalisa Savardi; Marco Borgogno; Roberto Narducci; Giuseppina La Sala; Jose Antonio Ortega; Maria Summa; Andrea Armirotti; Rosalia Bertorelli; Andrea Contestabile; Marco De Vivo; Laura Cancedda
Journal:  Chem       Date:  2020-08-06       Impact factor: 22.804
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.