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Literature DB >> 33772226

The role of GABAergic signalling in neurodevelopmental disorders.

Xin Tang^1,2, Rudolf Jaenisch³, Mriganka Sur⁴.

Abstract

GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of exciting new discoveries provides compelling evidence that disruptions in a number of key facets of GABAergic inhibition have critical roles in the aetiology of neurodevelopmental disorders (NDDs). These facets include the generation, migration and survival of GABAergic neurons, the formation of GABAergic synapses and circuit connectivity, and the dynamic regulation of the efficacy of GABAergic signalling through neuronal chloride transporters. In this Review, we discuss recent work that elucidates the functions and dysfunctions of GABAergic signalling in health and disease, that uncovers the contribution of GABAergic neural circuit dysfunction to NDD aetiology and that leverages such mechanistic insights to advance precision medicine for the treatment of NDDs.

Entities: Chemical

Mesh：

Substances：
gamma-Aminobutyric Acid

Year: 2021 PMID： 33772226 PMCID： PMC9001156 DOI： 10.1038/s41583-021-00443-x

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

230 in total

1. GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development.

Authors: Tue G Banke; Chris J McBain
Journal: J Neurosci Date: 2006-11-08 Impact factor: 6.167

2. Contribution of common and rare variants of the PTCHD1 gene to autism spectrum disorders and intellectual disability.

Authors: Bàrbara Torrico; Noèlia Fernàndez-Castillo; Amaia Hervás; Montserrat Milà; Marta Salgado; Isabel Rueda; Jan K Buitelaar; Nanda Rommelse; Anoek M Oerlemans; Janita Bralten; Christine M Freitag; Andreas Reif; Agatino Battaglia; Luigi Mazzone; Elena Maestrini; Bru Cormand; Claudio Toma
Journal: Eur J Hum Genet Date: 2015-03-18 Impact factor: 4.246

3. Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism.

Authors: Camila Oliveira Freitas Machado; Karina Griesi-Oliveira; Carla Rosenberg; Fernando Kok; Stephanie Martins; Maria Rita Passos-Bueno; Andrea Laurato Sertie
Journal: Eur J Hum Genet Date: 2015-04-22 Impact factor: 4.246

4. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

Authors: Alberto C S Costa; Michael J Grybko
Journal: Neurosci Lett Date: 2005-04-12 Impact factor: 3.046

5. Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat.

Authors: Marco D Brockmann; Beatrice Pöschel; Nicole Cichon; Ileana L Hanganu-Opatz
Journal: Neuron Date: 2011-07-28 Impact factor: 17.173

6. Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations.

Authors: Guang Chen; Yuan Zhang; Xiang Li; Xiaochen Zhao; Qian Ye; Yingxi Lin; Huizhong W Tao; Malte J Rasch; Xiaohui Zhang
Journal: Neuron Date: 2017-12-20 Impact factor: 17.173

7. Molecular reconstitution of functional GABAergic synapses with expression of neuroligin-2 and GABAA receptors.

Authors: Ning Dong; Jinshun Qi; Gong Chen
Journal: Mol Cell Neurosci Date: 2007-01-30 Impact factor: 4.314

8. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.

Authors: Elissar Andari; Jean-René Duhamel; Tiziana Zalla; Evelyn Herbrecht; Marion Leboyer; Angela Sirigu
Journal: Proc Natl Acad Sci U S A Date: 2010-02-16 Impact factor: 11.205

9. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior.

Authors: Robert F Hunt; Kelly M Girskis; John L Rubenstein; Arturo Alvarez-Buylla; Scott C Baraban
Journal: Nat Neurosci Date: 2013-05-05 Impact factor: 24.884

10. Cerebellum-Specific Deletion of the GABA_A Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.

Authors: Stephanie Rudolph; Chong Guo; Stan L Pashkovski; Tomas Osorno; Winthrop F Gillis; Jeremy M Krauss; Hajnalka Nyitrai; Isabella Flaquer; Mahmoud El-Rifai; Sandeep Robert Datta; Wade G Regehr
Journal: Cell Rep Date: 2020-11-03 Impact factor: 9.423

15 in total

Review 1. Allostery, and how to define and measure signal transduction.

Authors: Ruth Nussinov; Chung-Jung Tsai; Hyunbum Jang
Journal: Biophys Chem Date: 2022-01-29 Impact factor: 2.352

2. Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA.

Authors: Jian Liang; Dennis L H Kruijssen; Aniek C J Verschuuren; Bas J B Voesenek; Feline F W Benavides; Maria Sáez Gonzalez; Marvin Ruiter; Corette J Wierenga
Journal: J Neurosci Date: 2021-08-19 Impact factor: 6.167

3. FMRP regulates GABA_A receptor channel activity to control signal integration in hippocampal granule cells.

Authors: Pan-Yue Deng; Ajeet Kumar; Valeria Cavalli; Vitaly A Klyachko
Journal: Cell Rep Date: 2022-05-17 Impact factor: 9.995

Review 4. Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment.

Authors: Jessica Gama; Bianca Neves; Antonio Pereira
Journal: Front Microbiol Date: 2022-06-30 Impact factor: 6.064

5. Repeated Sevoflurane Exposure in Neonatal Rats Enhances the Sensitivity to Pain and Traumatic Stress Later in Juvenile Life.

Authors: Ben-Zhen Chen; Li-Hua Jiang; Wenqin Zhou; Yu-Chao Shang; Fang Li; Bin Liu
Journal: J Pain Res Date: 2022-10-12 Impact factor: 2.832

The role of GABAergic signalling in neurodevelopmental disorders.

1. GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development.

2. Contribution of common and rare variants of the PTCHD1 gene to autism spectrum disorders and intellectual disability.

3. Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism.

4. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

5. Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat.

6. Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations.

7. Molecular reconstitution of functional GABAergic synapses with expression of neuroligin-2 and GABAA receptors.

8. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.

9. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior.

10. Cerebellum-Specific Deletion of the GABA_A Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.

Review 1. Allostery, and how to define and measure signal transduction.

2. Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA.

3. FMRP regulates GABA_A receptor channel activity to control signal integration in hippocampal granule cells.

Review 4. Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment.

5. Repeated Sevoflurane Exposure in Neonatal Rats Enhances the Sensitivity to Pain and Traumatic Stress Later in Juvenile Life.

6. Serum metabolomics analysis of deficiency pattern and excess pattern in patients with rheumatoid arthritis.

Review 7. Keeping the Balance: GABA_B Receptors in the Developing Brain and Beyond.

8. Motor Cortex Excitation/Inhibition Imbalance in Young Adults With Autism Spectrum Disorder: A MRS-TMS Approach.

Review 9. Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission.

Review 10. Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins.

Review 1. Allostery, and how to define and measure signal transduction.

Review 4. Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment.

Review 7. Keeping the Balance: GABAB Receptors in the Developing Brain and Beyond.

Review 9. Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission.

Review 10. Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins.

Review 7. Keeping the Balance: GABA_B Receptors in the Developing Brain and Beyond.