Literature DB >> 29212578

To Treat or Not to Treat: The Effects of Pain on Experimental Parameters.

Norman C Peterson1, Elizabeth A Nunamaker2, Patricia V Turner3.   

Abstract

A common dilemma faced by all animal bioethics committees arises when exceptions are proposed to the use of analgesics in painful procedures. The committee and researcher must weigh the possible confounding effects of including additional drugs (analgesics) in their treatment regimen against the moral obligation to perform humane research. Often neglected in these considerations are the potential confounding effects of unrelieved pain and consistency with pain-relieving practices in human medicine. In this review, we summarize what is currently known regarding the molecular and physiologic effects of pain and analgesics in common animal models used across several therapeutic areas. This work is intended to help provide guidance and assurance that a comprehensive approach has been taken when contemplating how pain relief will be applied in animal research protocols.

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Year:  2017        PMID： 29212578      PMCID： PMC5713161     

Source DB:  PubMed          Journal:  Comp Med        ISSN： 1532-0820            Impact factor:   0.982


  132 in total

Review 1.  Animal models of ischemic stroke: balancing experimental aims and animal care.

Authors:  Sharon M Graham; Louise D McCullough; Stephanie J Murphy
Journal:  Comp Med       Date:  2004-10       Impact factor: 0.982

2.  The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia.

Authors:  Kumi Kaneko; Masato Umehara; Takashi Homan; Ken Okamoto; Michiko Oka; Tatsuya Oyama
Journal:  Neurosci Lett       Date:  2014-01-09       Impact factor: 3.046

3.  Restraint stress slows cutaneous wound healing in mice.

Authors:  D A Padgett; P T Marucha; J F Sheridan
Journal:  Brain Behav Immun       Date:  1998-03       Impact factor: 7.217

4.  Effects of buprenorphine on immunogenicity and protective efficacy in the guinea pig keratoconjunctivitis model (Sereny test).

Authors:  C E Hanson; G R Ruble; I Essiet; A B Hartman
Journal:  Comp Med       Date:  2001-06       Impact factor: 0.982

5.  Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model.

Authors:  J P A M van Loon; J C de Grauw; M van Dierendonck; J J L'ami; W Back; P R van Weeren
Journal:  Equine Vet J       Date:  2010-07       Impact factor: 2.888

6.  Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs.

Authors:  Qian Tan; Zihao Lin; Wenxi Ma; Huairen Chen; Lei Wang; Guansen Ning; Xu Zhou
Journal:  Burns       Date:  2002-08       Impact factor: 2.744

Review 7.  The role of analgesics in cancer propagation.

Authors:  Jonathan R Meserve; Alan David Kaye; Amit Prabhakar; Richard D Urman
Journal:  Best Pract Res Clin Anaesthesiol       Date:  2014-05-22

8.  Evaluation of butorphanol tartrate and buprenorphine hydrochloride on the inflammatory reaction of the Sereny Test.

Authors:  J R Swearengen; R A Cockman-Thomas; J A Davis; P J Weina
Journal:  Lab Anim Sci       Date:  1993-10

9.  Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice.

Authors:  Lisa Koodie; Hongyan Yuan; Jeffery A Pumper; Haidong Yu; Richard Charboneau; Sundaram Ramkrishnan; Sabita Roy
Journal:  Am J Pathol       Date:  2014-02-01       Impact factor: 4.307

10.  Anti-inflammatory effects of intra-articular administration of morphine in horses with experimentally induced synovitis.

Authors:  Casper Lindegaard; Karina B Gleerup; Maj H Thomsen; Torben Martinussen; Stine Jacobsen; Pia H Andersen
Journal:  Am J Vet Res       Date:  2010-01       Impact factor: 1.156
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  23 in total

1.  Pain as a Clinical Factor and Experimental Variable in Research Rodents.

Authors:  Mark A Suckow; Patricia V Turner
Journal:  Comp Med       Date:  2019-05-30       Impact factor: 0.982

2.  Ethical and IACUC Considerations Regarding Analgesia and Pain Management in Laboratory Rodents.

Authors:  Larry Carbone
Journal:  Comp Med       Date:  2019-08-27       Impact factor: 0.982

3.  Effects of Analgesics on Tumor Growth in Mouse Models of Prostate Cancer Bone Metastasis.

Authors:  Jiajie J Xu; Sarah E Thurston; Tyler J Robinson; June F Escara-Wilke; Stephanie Daignault-Newton; Tara L Martin; Evan T Keller; Jill M Keller
Journal:  J Am Assoc Lab Anim Sci       Date:  2021-05-03       Impact factor: 1.232

4.  Immunomodulation Associated with Sustained-release Buprenorphine in Female CD1 Mice Challenged with Ovalbumin.

Authors:  Alexis A Allen; Lon V Kendall
Journal:  J Am Assoc Lab Anim Sci       Date:  2019-07-18       Impact factor: 1.232

5.  Influence of Pain and Analgesia on Cancer Research Studies.

Authors:  Douglas K Taylor
Journal:  Comp Med       Date:  2019-07-17       Impact factor: 0.982

6.  Effects of Buprenorphine, Chlorhexidine, and Low-level Laser Therapy on Wound Healing in Mice.

Authors:  Donna R Webb; Sheba R Churchill; Georgette D Hill; Christopher A McGee; Min Shi; Angela P King-Herbert; Terry L Blankenship-Paris
Journal:  Comp Med       Date:  2021-04-16       Impact factor: 0.982

7.  Analgesia and Humane Endpoints for Rodents in Sepsis Research.

Authors:  Christine A Boehm; Jean A Nemzek
Journal:  Methods Mol Biol       Date:  2021

8.  Clinical Management of Pain in Rodents.

Authors:  Patricia L Foley; Lon V Kendall; Patricia V Turner
Journal:  Comp Med       Date:  2019-12-10       Impact factor: 0.982

Review 9.  A Review of Pain Assessment Methods in Laboratory Rodents.

Authors:  Patricia V Turner; Daniel Sj Pang; Jennifer Ls Lofgren
Journal:  Comp Med       Date:  2019-12-20       Impact factor: 0.982

Review 10.  A Review of the Effects of Pain and Analgesia on Immune System Function and Inflammation: Relevance for Preclinical Studies.

Authors:  George J DeMarco; Elizabeth A Nunamaker
Journal:  Comp Med       Date:  2019-12-20       Impact factor: 0.982
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