Literature DB >> 29209649

Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy.

Xiaolei Pan1, Naveed Ahmed1, Joyce Kong1, Dong Zhang1.   

Abstract

We recently reported that depletion of FANCM in ALT cells induces replication stress mainly at their telomeres. Additionally, we found that co-depletion of FANCM and BLM, or FANCM and BRCA1 induces synthetic lethality in the ALT cells. Our new findings could have important implications for cancer prevention and treatment.

Entities:  

Keywords:  ALT telomere; BLM; BRCA1; FANCM; replication stress

Year:  2017        PMID： 29209649      PMCID： PMC5706943          DOI： 10.1080/23723556.2017.1360978

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

Review 1.  Principles for the buffering of genetic variation.

Authors:  J L Hartman; B Garvik; L Hartwell
Journal:  Science       Date:  2001-02-09       Impact factor: 47.728

2.  FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.

Authors:  Xiaolei Pan; William C Drosopoulos; Louisa Sethi; Advaitha Madireddy; Carl L Schildkraut; Dong Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-03       Impact factor: 11.205

3.  Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.

Authors:  Cristian Tomasetti; Lu Li; Bert Vogelstein
Journal:  Science       Date:  2017-03-24       Impact factor: 47.728

4.  Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.

Authors:  Cristian Tomasetti; Bert Vogelstein
Journal:  Science       Date:  2015-01-02       Impact factor: 47.728

Review 5.  Causes and consequences of replication stress.

Authors:  Michelle K Zeman; Karlene A Cimprich
Journal:  Nat Cell Biol       Date:  2014-01       Impact factor: 28.824

6.  A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

Authors:  Giang Huong Nguyen; Thomas S Dexheimer; Andrew S Rosenthal; Wai Kit Chu; Dharmendra Kumar Singh; Georgina Mosedale; Csanád Z Bachrati; Lena Schultz; Masaaki Sakurai; Pavel Savitsky; Mika Abu; Peter J McHugh; Vilhelm A Bohr; Curtis C Harris; Ajit Jadhav; Opher Gileadi; David J Maloney; Anton Simeonov; Ian D Hickson
Journal:  Chem Biol       Date:  2013-01-24

Review 7.  Replication stress: getting back on track.

Authors:  Matteo Berti; Alessandro Vindigni
Journal:  Nat Struct Mol Biol       Date:  2016-02       Impact factor: 15.369
  7 in total
  5 in total

Review 1.  Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies.

Authors:  Jixuan Gao; Hilda A Pickett
Journal:  Nat Rev Cancer       Date:  2022-07-05       Impact factor: 69.800

Review 2.  Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

Authors:  Eva Petermann; Li Lan; Lee Zou
Journal:  Nat Rev Mol Cell Biol       Date:  2022-04-22       Impact factor: 113.915

Review 3.  PML nuclear bodies and chromatin dynamics: catch me if you can!

Authors:  Armelle Corpet; Constance Kleijwegt; Simon Roubille; Franceline Juillard; Karine Jacquet; Pascale Texier; Patrick Lomonte
Journal:  Nucleic Acids Res       Date:  2020-12-02       Impact factor: 16.971

Review 4.  Regulation of Replication Stress in Alternative Lengthening of Telomeres by Fanconi Anaemia Protein.

Authors:  Duda Li; Kailong Hou; Ke Zhang; Shuting Jia
Journal:  Genes (Basel)       Date:  2022-01-20       Impact factor: 4.096

5.  FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.

Authors:  Xiaolei Pan; Yun Chen; Beena Biju; Naveed Ahmed; Joyce Kong; Marti Goldenberg; Judy Huang; Nandakumar Mohan; Stephanie Klosek; Kian Parsa; Chia-Yu Guh; Robert Lu; Hilda A Pickett; Hsueh-Ping Chu; Dong Zhang
Journal:  Sci Rep       Date:  2019-12-13       Impact factor: 4.379
  5 in total

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