| Literature DB >> 29190362 |
Ryan Kelley1,2, Oliver Flouty3, Eric B Emmons2, Youngcho Kim4, Johnathan Kingyon5, Jan R Wessel4, Hiroyuki Oya3, Jeremy D Greenlee3, Nandakumar S Narayanan4.
Abstract
The subthalamic nucleus is a key site controlling motor function in humans. Deep brain stimulation of the subthalamic nucleus can improve movements in patients with Parkinson's disease; however, for unclear reasons, it can also have cognitive effects. Here, we show that the human subthalamic nucleus is monosynaptically connected with cognitive brain areas such as the prefrontal cortex. Single neurons and field potentials in the subthalamic nucleus are modulated during cognitive processing and are coherent with 4-Hz oscillations in medial prefrontal cortex. These data predict that low-frequency deep brain stimulation may alleviate cognitive deficits in Parkinson's disease patients. In line with this idea, we found that novel 4-Hz deep brain stimulation of the subthalamic nucleus improved cognitive performance. These data support a role for the human hyperdirect pathway in cognitive control, which could have relevance for brain-stimulation therapies aimed at cognitive symptoms of human brain disease.awx300media15660002226001.Entities:
Keywords: Parkinson’s disease; cognitive control; deep brain stimulation; hyperdirect pathway; subthalamic nucleus
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Year: 2018 PMID： 29190362 PMCID： PMC5837669 DOI： 10.1093/brain/awx300
Source DB: PubMed Journal: Brain ISSN： 0006-8950 Impact factor: 13.501