Literature DB >> 31373533

Medial prefrontal cortex in neurological diseases.

Pan Xu1, Ai Chen2, Yipeng Li3, Xuezhi Xing1, Hui Lu1.   

Abstract

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer's disease, Parkinson's disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.

Entities:  

Keywords:  cortical region; medial prefrontal cortex; neural circuit; neurological disease; pathophysiology

Mesh：

Year:  2019        PMID： 31373533      PMCID： PMC6766703          DOI： 10.1152/physiolgenomics.00006.2019

Source DB:  PubMed          Journal:  Physiol Genomics        ISSN： 1094-8341            Impact factor:   3.107


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