| Literature DB >> 29176623 |
Wei Chen1,2, Rui Tian2,3, Can Xu2, Bryant C Yung2, Guohao Wang3, Yijing Liu2, Qianqian Ni2, Fuwu Zhang2, Zijian Zhou2,3, Jingjing Wang2, Gang Niu2, Ying Ma2, Liwu Fu4, Xiaoyuan Chen5.
Abstract
The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli. In this manner, the system enables glucose-responsive and closed-loop release to significantly improve Ex4 therapeutic performance. Moreover, integration of mineralized particles can enhance the mechanical strength of alginate-based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invasive transdermal administration. We believe this smart glucose-responsive Ex4 delivery holds great promise for type 2 diabetes therapy by providing safe, long-term, and on-demand Ex4 therapy.Entities:
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Year: 2017 PMID： 29176623 PMCID： PMC5701150 DOI： 10.1038/s41467-017-01764-1
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919