| Literature DB >> 29170230 |
André M M Sousa1, Ying Zhu1, Mary Ann Raghanti2, Robert R Kitchen3,4, Marco Onorati1,5, Andrew T N Tebbenkamp1, Bernardo Stutz6, Kyle A Meyer1, Mingfeng Li1, Yuka Imamura Kawasawa1,7, Fuchen Liu1, Raquel Garcia Perez8, Marta Mele8, Tiago Carvalho8, Mario Skarica1, Forrest O Gulden1, Mihovil Pletikos1, Akemi Shibata1, Alexa R Stephenson2, Melissa K Edler2, John J Ely9, John D Elsworth4, Tamas L Horvath1,6, Patrick R Hof10, Thomas M Hyde11, Joel E Kleinman11, Daniel R Weinberger11, Mark Reimers12, Richard P Lifton13,14,15, Shrikant M Mane16, James P Noonan13, Matthew W State17, Ed S Lein18, James A Knowles19, Tomas Marques-Bonet8,20,21, Chet C Sherwood22, Mark B Gerstein3, Nenad Sestan23,4,6,13,24.
Abstract
To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type-specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex. Our integrated analysis of the generated data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.Entities:
Mesh：
Year: 2017 PMID： 29170230 PMCID： PMC5776074 DOI： 10.1126/science.aan3456
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728