| Literature DB >> 29154383 |
Miki Imanishi1, Shogo Tsuji, Akiyo Suda, Shiroh Futaki.
Abstract
We found that Escherichia coli MazF toxin, an ACA-sequence-specific endoribonuclease, was sensitive to N6-methyladenosine (m6A), representing the first m6A-sensitive RNA cleavage enzyme. The methyl-sensitivity of MazF allowed simple analyses of both m6A demethylase and methyltransferase activity. Furthermore, the approach could be used for inhibitor screening.Entities:
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Year: 2017 PMID： 29154383 DOI： 10.1039/c7cc07699a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222