| Literature DB >> 29153693 |
Krishna Singh1, John Williams2, Jordan Brown3, Erica T Wang4, Bora Lee5, Tania L Gonzalez5, Jinrui Cui6, Mark O Goodarzi7, Margareta D Pisarska8.
Abstract
MicroRNA (miRNA) expression has not been studied during placentation in pregnancies that develop preeclampsia, when it likely manifests. In this pilot study, miRNA expression in late first trimester placenta from four pregnancies that developed severe preeclampsia matched to controls using the Affymetrix GeneChip® miRNA 3.0 Array identified 9 miRNAs differentially expressed, with miR-202-3p the most significantly overexpressed in severe preeclampsia. Real-time reverse transcription polymerase chain reaction (qRT-PCR) confirmed overexpression of miR-202-3p in a validation cohort, with a 7-fold increase in pregnancies that developed severe preeclampsia (p≤0.05). Differential miRNA expression, specifically miR-202-3p, is seen in first trimester placenta in severe preeclampsia.Entities:
Keywords: Chorionic villus sampling (CVS); First trimester placenta; MicroRNA (miRNA); Preeclampsia
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Year: 2017 PMID： 29153693 PMCID： PMC5970562 DOI： 10.1016/j.preghy.2017.04.002
Source DB: PubMed Journal: Pregnancy Hypertens ISSN： 2210-7789 Impact factor: 2.899