OBJECTIVE: The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS: Microarray-based study was carried out with placental samples. RESULTS: Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets. CONCLUSION: The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.
OBJECTIVE: The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS: Microarray-based study was carried out with placental samples. RESULTS: Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets. CONCLUSION: The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.
Authors: Julio Mateus; Roger B Newman; Cuilin Zhang; Sarah J Pugh; Jagteshwar Grewal; Sungduk Kim; William A Grobman; John Owen; Anthony C Sciscione; Ronald J Wapner; Daniel Skupski; Edward Chien; Deborah A Wing; Angela C Ranzini; Michael P Nageotte; Nicole Gerlanc; Paul S Albert; Katherine L Grantz Journal: Am J Obstet Gynecol Date: 2019-06-19 Impact factor: 8.661
Authors: Mohammad L Rahman; Liming Liang; Linda Valeri; Li Su; Zhaozhong Zhu; Shangzhi Gao; Golam Mostofa; Qazi Qamruzzaman; Russ Hauser; Andrea Baccarelli; David C Christiani Journal: Epigenetics Date: 2018-08-13 Impact factor: 4.528
Authors: Krishna Singh; John Williams; Jordan Brown; Erica T Wang; Bora Lee; Tania L Gonzalez; Jinrui Cui; Mark O Goodarzi; Margareta D Pisarska Journal: Pregnancy Hypertens Date: 2017-05-08 Impact factor: 2.899