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Literature DB >> 29153196

Metabolic Biomarkers in Heart Failure.

Abstract

Metabolomics is the study of small, organic molecules within biochemical pathways. With advancement of technology, nuclear magnetic resonance, gas chromatography, and mass spectrometry have allowed for the discovery and analysis of large databases of metabolites implicated in heart failure. Metabolomics also explores the patient and environment interactions and unlocks the link between environmental exposures and the development of cardiovascular disease. Although a relatively new field, metabolomics is poised to become a clinically impactful field that develops novel biomarkers and explores new therapeutic interventions in heart failure.

Entities: Chemical Disease Gene Species

Keywords: Acylcarnitine; Arginine; Heart failure metabolomics; Myocardial energy utilization; Nitric oxide; TMAO

Mesh：

Substances：
Biomarkers

Year: 2018 PMID： 29153196 PMCID： PMC5708887 DOI： 10.1016/j.hfc.2017.08.011

Source DB: PubMed Journal: Heart Fail Clin ISSN： 1551-7136 Impact factor: 3.179

48 in total

Review 1. Metabolomics as a tool for cardiac research.

Authors: Julian L Griffin; Helen Atherton; John Shockcor; Luigi Atzori
Journal: Nat Rev Cardiol Date: 2011-09-20 Impact factor: 32.419

2. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.

Authors: Marc-Emmanuel Dumas; Richard H Barton; Ayo Toye; Olivier Cloarec; Christine Blancher; Alice Rothwell; Jane Fearnside; Roger Tatoud; Véronique Blanc; John C Lindon; Steve C Mitchell; Elaine Holmes; Mark I McCarthy; James Scott; Dominique Gauguier; Jeremy K Nicholson
Journal: Proc Natl Acad Sci U S A Date: 2006-08-08 Impact factor: 11.205

3. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis.

Authors: W H Wilson Tang; Zeneng Wang; Yiying Fan; Bruce Levison; Jennie E Hazen; Lillian M Donahue; Yuping Wu; Stanley L Hazen
Journal: J Am Coll Cardiol Date: 2014-10-27 Impact factor: 24.094

4. Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: diagnostic and prognostic value of metabolomics.

Authors: Mei-Ling Cheng; Chao-Hung Wang; Ming-Shi Shiao; Min-Hui Liu; Yu-Yen Huang; Cheng-Yu Huang; Chun-Tai Mao; Jui-Fen Lin; Hung-Yao Ho; Ning-I Yang
Journal: J Am Coll Cardiol Date: 2015-04-21 Impact factor: 24.094

5. Endothelial nitric oxide synthase polymorphism and prognosis in systolic heart failure patients.

Authors: Naiel Azzam; Barak Zafrir; Fuad Fares; Yoav Smith; Nabeeh Salman; Roman Nevzorov; Offer Amir
Journal: Nitric Oxide Date: 2015-04-23 Impact factor: 4.427

Review 6. The core gut microbiome, energy balance and obesity.

Authors: Peter J Turnbaugh; Jeffrey I Gordon
Journal: J Physiol Date: 2009-06-02 Impact factor: 5.182

Review 7. Using metabolomics to assess myocardial metabolism and energetics in heart failure.

Authors: Aslan T Turer
Journal: J Mol Cell Cardiol Date: 2012-09-07 Impact factor: 5.000

8. Nitrite therapy improves left ventricular function during heart failure via restoration of nitric oxide-mediated cytoprotective signaling.

Authors: Shashi Bhushan; Kazuhisa Kondo; David J Polhemus; Hiroyuki Otsuka; Chad K Nicholson; Ya-Xiong Tao; Hui Huang; Vasiliki V Georgiopoulou; Toyoaki Murohara; John W Calvert; Javed Butler; David J Lefer
Journal: Circ Res Date: 2014-03-05 Impact factor: 17.367

9. Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

Authors: Stephen C Kolwicz; Sophia Airhart; Rong Tian
Journal: Circulation Date: 2016-01-27 Impact factor: 29.690

10. Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.

Authors: Chelsea L Organ; Hiroyuki Otsuka; Shashi Bhushan; Zeneng Wang; Jessica Bradley; Rishi Trivedi; David J Polhemus; W H Wilson Tang; Yuping Wu; Stanley L Hazen; David J Lefer
Journal: Circ Heart Fail Date: 2015-12-23 Impact factor: 8.790

15 in total

Review 1. The gut microbiome and heart failure: A better gut for a better heart.

Authors: Maxime Branchereau; Rémy Burcelin; Christophe Heymes
Journal: Rev Endocr Metab Disord Date: 2019-12 Impact factor: 6.514

2. Following the Scent of Microbes Within: The Heart-Gut Connection.

Authors: Chonyang Lu Albert; W H Wilson Tang
Journal: J Card Fail Date: 2019-03-26 Impact factor: 5.712

3. Cardiovascular mechanobiology-a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease.

Authors: Pamela Swiatlowska; Thomas Iskratsch
Journal: Biophys Rev Date: 2021-09-11

4. Optimism, pessimism, and health biomarkers in older couples.

Authors: Reout Arbel; Dikla Segel-Karpas; William Chopik
Journal: Br J Health Psychol Date: 2020-09-10

Review 5. Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.

Authors: Siyu He; Hong Jiang; Caili Zhuo; Wei Jiang
Journal: Cardiovasc Toxicol Date: 2021-05-18 Impact factor: 3.231

6. A metabolomic study for chronic heart failure patients based on a dried blood spot mass spectrometry approach.

Authors: Gaowa Zhao; Dong Cheng; Yu Wang; Yalan Cao; Shuting Xiang; Qin Yu
Journal: RSC Adv Date: 2020-05-22 Impact factor: 4.036

7. Novel Findings From a Metabolomics Study of Left Ventricular Diastolic Function: The Bogalusa Heart Study.

Authors: Alexander C Razavi; Lydia A Bazzano; Jiang He; Camilo Fernandez; Seamus P Whelton; Marie Krousel-Wood; Shengxu Li; Jovia L Nierenberg; Mengyao Shi; Changwei Li; Xuenan Mi; Jason Kinchen; Tanika N Kelly
Journal: J Am Heart Assoc Date: 2020-01-29 Impact factor: 5.501