Literature DB >> 33540894

Mitochondrial Homeostasis Mediates Lipotoxicity in the Failing Myocardium.

Tom Kretzschmar1, Jasmine M F Wu1, P Christian Schulze1.   

Abstract

Heart failure remains the most common cause of death in the industrialized world. In spite of new therapeutic interventions that are constantly being developed, it is still not possible to completely protect against heart failure development and progression. This shows how much more research is necessary to understand the underlying mechanisms of this process. In this review, we give a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression. In particular, we focus on the regulation of fatty acid metabolism and the effects of fatty acid accumulation on mitochondrial structural and functional homeostasis.

Entities:  

Keywords:  heart failure; lipotoxicity; metabolism; mitochondrial homeostasis

Mesh：

Substances：

Year:  2021        PMID： 33540894      PMCID： PMC7867320          DOI： 10.3390/ijms22031498

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  242 in total

Review 1.  Building a complex complex: Assembly of mitochondrial respiratory chain complex I.

Authors:  Luke E Formosa; Marris G Dibley; David A Stroud; Michael T Ryan
Journal:  Semin Cell Dev Biol       Date:  2017-08-07       Impact factor: 7.727

2.  Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury.

Authors:  Sang-Bing Ong; Sapna Subrayan; Shiang Y Lim; Derek M Yellon; Sean M Davidson; Derek J Hausenloy
Journal:  Circulation       Date:  2010-04-26       Impact factor: 29.690

3.  Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction.

Authors:  Su-Yeon Lee; Jung Ran Kim; Yunying Hu; Raffay Khan; Su-Jung Kim; Kalyani G Bharadwaj; Mercy M Davidson; Cheol-Soo Choi; Kyong-Oh Shin; Yong-Moon Lee; Woo-Jin Park; In-Sun Park; Xian-Cheng Jiang; Ira J Goldberg; Tae-Sik Park
Journal:  J Biol Chem       Date:  2012-04-09       Impact factor: 5.157

4.  Mitofusin 2 tethers endoplasmic reticulum to mitochondria.

Authors:  Olga Martins de Brito; Luca Scorrano
Journal:  Nature       Date:  2008-12-04       Impact factor: 49.962

5.  Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.

Authors:  Tae-Sik Park; Yunying Hu; Hye-Lim Noh; Konstantinos Drosatos; Kazue Okajima; Jonathan Buchanan; Joseph Tuinei; Shunichi Homma; Xian-Cheng Jiang; E Dale Abel; Ira J Goldberg
Journal:  J Lipid Res       Date:  2008-05-30       Impact factor: 5.922

6.  Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Authors:  Kenneth C Bedi; Nathaniel W Snyder; Jeffrey Brandimarto; Moez Aziz; Clementina Mesaros; Andrew J Worth; Linda L Wang; Ali Javaheri; Ian A Blair; Kenneth B Margulies; J Eduardo Rame
Journal:  Circulation       Date:  2016-01-27       Impact factor: 29.690

7.  Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma.

Authors:  Zheng Wang; Lijun Wen; Fei Zhu; Yanping Wang; Qing Xie; Zijun Chen; Yunsen Li
Journal:  Oncotarget       Date:  2017-10-23

8.  MiD49 and MiD51: New mediators of mitochondrial fission and novel targets for cardioprotection.

Authors:  Parisa Samangouei; Gustavo E Crespo-Avilan; Hector Cabrera-Fuentes; Sauri Hernández-Reséndiz; Nur Izzah Ismail; Khairunnisa Binte Katwadi; William A Boisvert; Derek J Hausenloy
Journal:  Cond Med       Date:  2018-08

9.  Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.

Authors:  Marie-Hélène Disatnik; Julio C B Ferreira; Juliane Cruz Campos; Kátia Sampaio Gomes; Paulo M M Dourado; Xin Qi; Daria Mochly-Rosen
Journal:  J Am Heart Assoc       Date:  2013-10-08       Impact factor: 5.501

Review 10.  Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms.

Authors:  Alessandra Alí; Mohamed Boutjdir; Ademuyiwa S Aromolaran
Journal:  Front Physiol       Date:  2019-01-07       Impact factor: 4.566
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  2 in total

1.  Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.

Authors:  Xue Tian; Xu Chen; Qianqian Jiang; Qianbin Sun; Tiantian Liu; Yiqin Hong; Yawen Zhang; Yanyan Jiang; Mingyan Shao; Ran Yang; Chun Li; Qiyan Wang; Yong Wang
Journal:  Front Pharmacol       Date:  2022-03-17       Impact factor: 5.810

2.  Protecting the Mitochondria in Cardiac Disease.

Authors:  Antigone Lazou; Chrishan J Ramachandra
Journal:  Int J Mol Sci       Date:  2022-07-23       Impact factor: 6.208
  2 in total

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