B González-Alzaga1, M Lacasaña2, A F Hernández3, J P Arrebola4, I López-Flores5, F Artacho-Cordón6, J P Bonde7, N Olea8, C Aguilar-Garduño9. 1. Andalusian School of Public Health (EASP), Granada, Spain; Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. 2. Andalusian School of Public Health (EASP), Granada, Spain; Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic address: marina.lacasana.easp@juntadeandalucia.es. 3. Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain. 4. Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Radiation Oncology Department, Virgen de las Nieves University Hospital, Granada, Spain. 5. Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Department of Genetics, Faculty of Sciences, University of Granada, Spain. 6. Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Department of Radiology and Physical Medicine, University of Granada, Granada, Spain. 7. Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, University of Copenhagen, Denmark. 8. Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Radiology and Physical Medicine, University of Granada, Granada, Spain. 9. Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental- Alejandro Otero, Spain.
Abstract
BACKGROUND: Information on exposure levels to organochlorine compounds (OCs) in child population is limited, despite their greater vulnerability to the adverse health effects of these chemicals. OBJECTIVE: To determine serum concentrations of 10 OCs (including organochlorine pesticides and polychlorinated biphenyls -PCBs-) in children living in agricultural communities from Almería (South-Eastern Spain), and to identify the main predictors of exposure related to socio-economic characteristics, diet and lifestyle. METHODS: A cross-sectional study was conducted on 133 children aged 6-11 years selected from public schools of the study area. OCs compounds were determined in serum samples by GC/ECD. Anthropometric measures were obtained during sample collection. Information on sociodemographic characteristics, parental occupation, residential history, lifestyle and frequency of food consumption, among other relevant factors, was obtained by questionnaires administered to the mothers. RESULTS: Geometric means of serum concentrations (ng/ml) were 0.11 for β-hexachloro-cyclohexane (β-HCH), 0.09 for endosulfan, 0.20 for endosulfan-ether, 0.51 for hexachorobenzene (HCB), 0.08 for mirex, 0.06 for oxychlordane, 0.36 for p,p'-DDE, 0.20 for PCB 138, 0.36 for PCB 153, and 0.45 for PCB 180. Percentage of samples above the limit of detection (0.05 ppb) ranged from 32 (β-HCH) to 100 (HCB). A high variability in OC levels depending on the compound was observed between our results and others found in similar studies carried out in children. Variables related to fish consumption were found to be the major dietary determinant of PCB 138, p,p´-DDE, endosulfan-α, β-HCH, mirex and oxychlordane levels. CONCLUSIONS: Children participating in this study showed detectable levels of many OC, despite these compounds are no longer used. Their presence in children serum can be explained by their high lipophilicity and environmental persistence, leading to contamination of fatty food. In this line, fish consumption seemed to be the most relevant determinant of OC levels found in our study.
BACKGROUND: Information on exposure levels to organochlorine compounds (OCs) in child population is limited, despite their greater vulnerability to the adverse health effects of these chemicals. OBJECTIVE: To determine serum concentrations of 10 OCs (including organochlorine pesticides and polychlorinated biphenyls -PCBs-) in children living in agricultural communities from Almería (South-Eastern Spain), and to identify the main predictors of exposure related to socio-economic characteristics, diet and lifestyle. METHODS: A cross-sectional study was conducted on 133 children aged 6-11 years selected from public schools of the study area. OCs compounds were determined in serum samples by GC/ECD. Anthropometric measures were obtained during sample collection. Information on sociodemographic characteristics, parental occupation, residential history, lifestyle and frequency of food consumption, among other relevant factors, was obtained by questionnaires administered to the mothers. RESULTS: Geometric means of serum concentrations (ng/ml) were 0.11 for β-hexachloro-cyclohexane (β-HCH), 0.09 for endosulfan, 0.20 for endosulfan-ether, 0.51 for hexachorobenzene (HCB), 0.08 for mirex, 0.06 for oxychlordane, 0.36 for p,p'-DDE, 0.20 for PCB 138, 0.36 for PCB 153, and 0.45 for PCB 180. Percentage of samples above the limit of detection (0.05 ppb) ranged from 32 (β-HCH) to 100 (HCB). A high variability in OC levels depending on the compound was observed between our results and others found in similar studies carried out in children. Variables related to fish consumption were found to be the major dietary determinant of PCB 138, p,p´-DDE, endosulfan-α, β-HCH, mirex and oxychlordane levels. CONCLUSIONS:Children participating in this study showed detectable levels of many OC, despite these compounds are no longer used. Their presence in children serum can be explained by their high lipophilicity and environmental persistence, leading to contamination of fatty food. In this line, fish consumption seemed to be the most relevant determinant of OC levels found in our study.
Authors: Nicolas López-Gálvez; Rietta Wagoner; Lesliam Quirós-Alcalá; Yoshira Ornelas Van Horne; Melissa Furlong; El'gin Avila; Paloma Beamer Journal: Int J Environ Res Public Health Date: 2019-06-19 Impact factor: 3.390
Authors: Inmaculada Salcedo-Bellido; Esperanza Amaya; Celia Pérez-Díaz; Anabel Soler; Fernando Vela-Soria; Pilar Requena; Rocío Barrios-Rodríguez; Ruth Echeverría; Francisco M Pérez-Carrascosa; Raquel Quesada-Jiménez; Piedad Martín-Olmedo; Juan Pedro Arrebola Journal: Int J Environ Res Public Health Date: 2022-03-11 Impact factor: 3.390