Literature DB >> 29128078

Applications of Mass Cytometry in Clinical Medicine: The Promise and Perils of Clinical CyTOF.

Gregory K Behbehani1.   

Abstract

Mass cytometry is a novel technology similar to flow cytometry in which antibodies are tagged with heavy metal molecules rather than fluorophores and then detected with time-of-flight mass spectrometry. This enables measurement of up to 50 simultaneous parameters with no autofluorescent background and little or no spillover or required compensation. Mass cytometry has tremendous potential for the analysis of highly complex clinical samples for the diagnosis and monitoring of malignant and autoimmune disorders. The technology also presents several unique challenges for clinical use and will require new approaches to analyze the large amounts of data generated.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Aberrant marker expression; Acute leukemia; CyTOF; Flow cytometry; Mass cytometry; Minimal residual disease

Mesh：

Substances：

Year:  2017        PMID： 29128078     DOI： 10.1016/j.cll.2017.07.010

Source DB:  PubMed          Journal:  Clin Lab Med        ISSN： 0272-2712            Impact factor:   1.935


  12 in total

Review 1.  A Cancer Biologist's Primer on Machine Learning Applications in High-Dimensional Cytometry.

Authors:  Timothy J Keyes; Pablo Domizi; Yu-Chen Lo; Garry P Nolan; Kara L Davis
Journal:  Cytometry A       Date:  2020-06-30       Impact factor: 4.355

Review 2.  The role of automated cytometry in the new era of cancer immunotherapy.

Authors:  Marco Danova; Martina Torchio; Giuditta Comolli; Andrea Sbrana; Andrea Antonuzzo; Giuliano Mazzini
Journal:  Mol Clin Oncol       Date:  2018-08-20

3.  Predicting leukemia relapse.

Authors:  José Ignacio Martín-Subero
Journal:  Nat Med       Date:  2018-04-10       Impact factor: 53.440

Review 4.  Beyond the message: advantages of snapshot proteomics with single-cell mass cytometry in solid tumors.

Authors:  Akshitkumar M Mistry; Allison R Greenplate; Rebecca A Ihrie; Jonathan M Irish
Journal:  FEBS J       Date:  2019-01-07       Impact factor: 5.542

Review 5.  Novel Technologies in Studying Brain Immune Response.

Authors:  Li Li; Cameron Lenahan; Zhihui Liao; Jingdong Ke; Xiuliang Li; Fushan Xue; John H Zhang
Journal:  Oxid Med Cell Longev       Date:  2021-03-18       Impact factor: 6.543

6.  Characterizing Highly Cited Papers in Mass Cytometry through H-Classics.

Authors:  Daniel E Di Zeo-Sánchez; Pablo Sánchez-Núñez; Camilla Stephens; M Isabel Lucena
Journal:  Biology (Basel)       Date:  2021-02-02

7.  CytofIn enables integrated analysis of public mass cytometry datasets using generalized anchors.

Authors:  Yu-Chen Lo; Timothy J Keyes; Astraea Jager; Jolanda Sarno; Pablo Domizi; Ravindra Majeti; Kathleen M Sakamoto; Norman Lacayo; Charles G Mullighan; Jeffrey Waters; Bita Sahaf; Sean C Bendall; Kara L Davis
Journal:  Nat Commun       Date:  2022-02-17       Impact factor: 17.694

8.  Polymeric dipicolylamine based mass tags for mass cytometry.

Authors:  Yefeng Zhang; Peng Liu; Daniel Majonis; Mitchell A Winnik
Journal:  Chem Sci       Date:  2022-02-23       Impact factor: 9.825

9.  A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates.

Authors:  Zachary B Bjornson-Hooper; Gabriela K Fragiadakis; Matthew H Spitzer; Han Chen; Deepthi Madhireddy; Kevin Hu; Kelly Lundsten; David R McIlwain; Garry P Nolan
Journal:  Front Immunol       Date:  2022-03-11       Impact factor: 7.561

10.  Laser Capture Microdissection Coupled Capillary Immunoassay to Study the Expression of PCK-2 on Spatially-Resolved Islets of Rat Langerhans.

Authors:  Shashank Pandey; Zdenek Tuma; Tereza Smrhova; Miroslava Cedikova; Tereza Macanova; Magdalena Chottova Dvorakova
Journal:  Pharmaceutics       Date:  2021-06-15       Impact factor: 6.321
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