Literature DB >> 33791073

Novel Technologies in Studying Brain Immune Response.

Li Li1, Cameron Lenahan2,3, Zhihui Liao1, Jingdong Ke1, Xiuliang Li1, Fushan Xue1, John H Zhang4,5.   

Abstract

Over the past few decades, the immune system, including both the adaptive and innate immune systems, proved to be essential and critical to brain damage and recovery in the pathogenesis of several diseases, opening a new avenue for developing new immunomodulatory therapies and novel treatments for many neurological diseases. However, due to the specificity and structural complexity of the central nervous system (CNS), and the limit of the related technologies, the biology of the immune response in the brain is still poorly understood. Here, we discuss the application of novel technologies in studying the brain immune response, including single-cell RNA analysis, cytometry by time-of-flight, and whole-genome transcriptomic and proteomic analysis. We believe that advancements in technology related to immune research will provide an optimistic future for brain repair.
Copyright © 2021 Li Li et al.

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Year:  2021        PMID： 33791073      PMCID： PMC7997736          DOI： 10.1155/2021/6694566

Source DB:  PubMed          Journal:  Oxid Med Cell Longev        ISSN： 1942-0994            Impact factor:   6.543


  75 in total

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3.  Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome.

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Journal:  Eur J Immunol       Date:  2019-09-11       Impact factor: 5.532

4.  Stochastic regulation in early immune response.

Authors:  Tomasz Lipniacki; Pawel Paszek; Allan R Brasier; Bruce A Luxon; Marek Kimmel
Journal:  Biophys J       Date:  2005-11-11       Impact factor: 4.033

5.  Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.

Authors:  Qingyun Li; Zuolin Cheng; Lu Zhou; Spyros Darmanis; Norma F Neff; Jennifer Okamoto; Gunsagar Gulati; Mariko L Bennett; Lu O Sun; Laura E Clarke; Julia Marschallinger; Guoqiang Yu; Stephen R Quake; Tony Wyss-Coray; Ben A Barres
Journal:  Neuron       Date:  2018-12-31       Impact factor: 17.173

6.  Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.

Authors:  Holger Winkels; Erik Ehinger; Melanie Vassallo; Konrad Buscher; Huy Q Dinh; Kouji Kobiyama; Anouk A J Hamers; Clément Cochain; Ehsan Vafadarnejad; Antoine-Emmanuel Saliba; Alma Zernecke; Akula Bala Pramod; Amlan K Ghosh; Nathaly Anto Michel; Natalie Hoppe; Ingo Hilgendorf; Andreas Zirlik; Catherine C Hedrick; Klaus Ley; Dennis Wolf
Journal:  Circ Res       Date:  2018-03-15       Impact factor: 17.367

7.  Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin.

Authors:  James C Ryan; Qingzhong Wu; Ritchie C Shoemaker
Journal:  BMC Med Genomics       Date:  2015-04-02       Impact factor: 3.063

8.  Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.

Authors:  Jessica Galloway-Peña; Sruti DebRoy; Chelcy Brumlow; Xiqi Li; Truc T Tran; Nicola Horstmann; Hui Yao; Ken Chen; Fang Wang; Bih-Fang Pan; David H Hawke; Erika J Thompson; Cesar A Arias; Vance G Fowler; Micah M Bhatti; Awdhesh Kalia; Anthony R Flores; Samuel A Shelburne
Journal:  PLoS One       Date:  2018-12-05       Impact factor: 3.752

9.  Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance.

Authors:  Eun-Ah Christine Song; Sangwon Min; Akinsola Oyelakin; Kirsten Smalley; Jonathan E Bard; Lan Liao; Jianming Xu; Rose-Anne Romano
Journal:  Sci Rep       Date:  2018-09-19       Impact factor: 4.379

10.  Reliability of human cortical organoid generation.

Authors:  Se-Jin Yoon; Lubayna S Elahi; Anca M Pașca; Rebecca M Marton; Aaron Gordon; Omer Revah; Yuki Miura; Elisabeth M Walczak; Gwendolyn M Holdgate; H Christina Fan; John R Huguenard; Daniel H Geschwind; Sergiu P Pașca
Journal:  Nat Methods       Date:  2018-12-20       Impact factor: 28.547
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  2 in total

1.  Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue.

Authors:  Madison Trujillo; Taylor McElroy; Taurean Brown; Pilar Simmons; Fabio Ntagwabira; Antiño R Allen
Journal:  J Vis Exp       Date:  2021-10-21       Impact factor: 1.424

2.  An ischemia-homing bioengineered nano-scavenger for specifically alleviating multiple pathogeneses in ischemic stroke.

Authors:  Ranran Duan; Ke Sun; Fang Fang; Ning Wang; Ruya He; Yang Gao; Lijun Jing; Yanfei Li; Zhe Gong; Yaobing Yao; Tingting Luan; Chaopeng Zhang; Jinwei Zhang; Yi Zhao; Haojie Xie; Yongyan Zhou; Junfang Teng; Jinfeng Zhang; Yanjie Jia
Journal:  J Nanobiotechnology       Date:  2022-08-31       Impact factor: 9.429
  2 in total

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