Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Nonsense-mediated mRNA Decay and Cancer.

Literature DB >> 29121514

Nonsense-mediated mRNA Decay and Cancer.

Abstract

Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role of NMD in cancer development is complex. In some cases, tumors have exploited NMD to downregulate gene expression by apparently selecting for mutations causing destruction of key tumor-suppressor mRNAs. In other cases, tumors adjust NMD activity to adapt to their microenvironment. Understanding how particular tumors exploit NMD for their benefit may augment the development of new therapeutic interventions.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2017 PMID： 29121514 PMCID： PMC5869107 DOI： 10.1016/j.gde.2017.10.007

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

52 in total

1. Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1.

Authors: S Fan; R Yuan; Y X Ma; Q Meng; I D Goldberg; E M Rosen
Journal: Oncogene Date: 2001-12-13 Impact factor: 9.867

2. The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons.

Authors: Laure Perrin-Vidoz; Olga M Sinilnikova; Dominique Stoppa-Lyonnet; Gilbert M Lenoir; Sylvie Mazoyer
Journal: Hum Mol Genet Date: 2002-11-01 Impact factor: 6.150

Review 3. Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.

Authors: Lawrence B Gardner
Journal: Mol Cancer Res Date: 2010-02-23 Impact factor: 5.852

4. Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response.

Authors: Lawrence B Gardner
Journal: Mol Cell Biol Date: 2008-03-24 Impact factor: 4.272

5. Dominant-negative activity of a Brca1 truncation mutant: effects on proliferation, tumorigenicity in vivo, and chemosensitivity in a mouse ovarian cancer cell line.

Authors: Valerie Sylvain; Stephane Lafarge; Yves-Jean Bignon
Journal: Int J Oncol Date: 2002-04 Impact factor: 5.650

6. The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors.

Authors: JingWei Lu; Terra-Dawn Plank; Fang Su; XiuJuan Shi; Chen Liu; Yuan Ji; ShuaiJun Li; Andrew Huynh; Chao Shi; Bo Zhu; Guang Yang; YanMing Wu; Miles F Wilkinson; YanJun Lu
Journal: J Clin Invest Date: 2016-06-27 Impact factor: 14.808

7. The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.

Authors: Claus M Azzalin; Joachim Lingner
Journal: Curr Biol Date: 2006-02-21 Impact factor: 10.834

8. Inhibition of nonsense-mediated RNA decay activates autophagy.

Authors: Jordan Wengrod; Leenus Martin; Ding Wang; Pamela Frischmeyer-Guerrerio; Harry C Dietz; Lawrence B Gardner
Journal: Mol Cell Biol Date: 2013-03-18 Impact factor: 4.272

Review 9. Cancer Microenvironment and Endoplasmic Reticulum Stress Response.

Authors: Claudia Giampietri; Simonetta Petrungaro; Silvia Conti; Antonio Facchiano; Antonio Filippini; Elio Ziparo
Journal: Mediators Inflamm Date: 2015-09-27 Impact factor: 4.711

10. Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability.

Authors: Jonathan O Nelson; Kristin A Moore; Alex Chapin; Julie Hollien; Mark M Metzstein
Journal: Elife Date: 2016-03-08 Impact factor: 8.140

47 in total

1. Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity.

Authors: Wangchao Xu; Puhua Bao; Xin Jiang; Haifang Wang; Meiling Qin; Ruiqi Wang; Tao Wang; Yi Yang; Ileana Lorenzini; Lujian Liao; Rita Sattler; Jin Xu
Journal: Brain Date: 2019-05-01 Impact factor: 13.501

2. Global Profiling of Cellular Substrates of Human Dcp2.

Authors: Yang Luo; Jeremy A Schofield; Matthew D Simon; Sarah A Slavoff
Journal: Biochemistry Date: 2020-05-14 Impact factor: 3.162

Review 3. Proteomic and interactomic insights into the molecular basis of cell functional diversity.

Authors: Isabell Bludau; Ruedi Aebersold
Journal: Nat Rev Mol Cell Biol Date: 2020-03-31 Impact factor: 94.444

Review 4. Cellular RNA surveillance in health and disease.

Authors: Sandra L Wolin; Lynne E Maquat
Journal: Science Date: 2019-11-14 Impact factor: 47.728

5. Integrative transcriptomic analysis suggests new autoregulatory splicing events coupled with nonsense-mediated mRNA decay.

Authors: Dmitri Pervouchine; Yaroslav Popov; Andy Berry; Beatrice Borsari; Adam Frankish; Roderic Guigó
Journal: Nucleic Acids Res Date: 2019-06-04 Impact factor: 16.971

Review 6. Nonsense-mediated RNA decay: an emerging modulator of malignancy.

Authors: Kun Tan; Dwayne G Stupack; Miles F Wilkinson
Journal: Nat Rev Cancer Date: 2022-05-27 Impact factor: 69.800

Review 7. Roles and mechanisms of alternative splicing in cancer - implications for care.

Authors: Sophie C Bonnal; Irene López-Oreja; Juan Valcárcel
Journal: Nat Rev Clin Oncol Date: 2020-04-17 Impact factor: 66.675

Review 8. Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.

Authors: Laura M Urbanski; Nathan Leclair; Olga Anczuków
Journal: Wiley Interdiscip Rev RNA Date: 2018-04-25 Impact factor: 9.957

9. Alternative splicing of leptin receptor overlapping transcript in osteosarcoma.

Authors: Emel Rothzerg; Xuan D Ho; Jiake Xu; David Wood; Aare Märtson; Katre Maasalu; Sulev Kõks
Journal: Exp Biol Med (Maywood) Date: 2020-08-12

Review 10. RNA Dysregulation: An Expanding Source of Cancer Immunotherapy Targets.

Authors: Yang Pan; Kathryn E Kadash-Edmondson; Robert Wang; John Phillips; Song Liu; Antoni Ribas; Richard Aplenc; Owen N Witte; Yi Xing
Journal: Trends Pharmacol Sci Date: 2021-04 Impact factor: 14.819