Literature DB >> 32787464

Alternative splicing of leptin receptor overlapping transcript in osteosarcoma.

Emel Rothzerg1,2, Xuan D Ho3, Jiake Xu1, David Wood1, Aare Märtson4, Katre Maasalu4, Sulev Kõks2,5.   

Abstract

IMPACT STATEMENT: Osteosarcoma (OS, also known as osteogenic sarcoma) is the most common primary malignancy of bone in children and adolescents. The molecular mechanisms of OS are extremely complicated and its molecular mediators remain to be elucidated. We sequenced total RNA from 18 OS bone samples (paired normal-tumor biopsies). We found statistically significant (FDR <0.05) 26 differentially expressed transcript variants of LEPROT gene with different expressions in normal and tumor samples. These findings contribute to the understanding of molecular mechanisms of OS development and provide encouragement to pursue further research.

Entities:  

Keywords:  LEPROT; Osteosarcoma; RNA sequencing; alternative splicing; osteogenic sarcoma; transcriptome

Year:  2020        PMID： 32787464      PMCID： PMC7553092          DOI： 10.1177/1535370220949139

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  60 in total

1.  Normalization, testing, and false discovery rate estimation for RNA-sequencing data.

Authors:  Jun Li; Daniela M Witten; Iain M Johnstone; Robert Tibshirani
Journal:  Biostatistics       Date:  2011-10-14       Impact factor: 5.899

Review 2.  Signal transduction via the growth hormone receptor.

Authors:  T Zhu; E L Goh; R Graichen; L Ling; P E Lobie
Journal:  Cell Signal       Date:  2001-09       Impact factor: 4.315

Review 3.  Aberrant and alternative splicing in cancer.

Authors:  Julian P Venables
Journal:  Cancer Res       Date:  2004-11-01       Impact factor: 12.701

4.  Whole transcriptome analysis identifies differentially regulated networks between osteosarcoma and normal bone samples.

Authors:  Xuan Dung Ho; Phuong Phung; Van Q Le; Van H Nguyen; Ene Reimann; Ele Prans; Gea Kõks; Katre Maasalu; Nghi Tn Le; Le H Trinh; Hoang G Nguyen; Aare Märtson; Sulev Kõks
Journal:  Exp Biol Med (Maywood)       Date:  2017-10-19

5.  Interleukin-6 upregulates SOX18 expression in osteosarcoma.

Authors:  Zhong Wu; Weizhi Yang; Junjian Liu; Fan Zhang
Journal:  Onco Targets Ther       Date:  2017-11-08       Impact factor: 4.147

6.  Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis.

Authors:  Hao Jin; Xin Jin; Boran Cao; Wenbo Wang
Journal:  Oncol Rep       Date:  2016-12-16       Impact factor: 3.906

7.  RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing.

Authors:  Heidi Dvinge; Jamie Guenthoer; Peggy L Porter; Robert K Bradley
Journal:  Genome Res       Date:  2019-08-21       Impact factor: 9.043

8.  IL-6 Promotes Cancer Stemness and Oncogenicity in U2OS and MG-63 Osteosarcoma Cells by Upregulating the OPN-STAT3 Pathway.

Authors:  Chuan Zhang; Kun Ma; Wu-Yin Li
Journal:  J Cancer       Date:  2019-10-21       Impact factor: 4.207

9.  Comprehensive comparative analysis of strand-specific RNA sequencing methods.

Authors:  Joshua Z Levin; Moran Yassour; Xian Adiconis; Chad Nusbaum; Dawn Anne Thompson; Nir Friedman; Andreas Gnirke; Aviv Regev
Journal:  Nat Methods       Date:  2010-08-15       Impact factor: 28.547

Review 10.  Mechanism and regulation of the nonsense-mediated decay pathway.

Authors:  Nele Hug; Dasa Longman; Javier F Cáceres
Journal:  Nucleic Acids Res       Date:  2016-01-14       Impact factor: 16.971
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  4 in total

1.  Upregulation of 15 Antisense Long Non-Coding RNAs in Osteosarcoma.

Authors:  Emel Rothzerg; Xuan Dung Ho; Jiake Xu; David Wood; Aare Märtson; Sulev Kõks
Journal:  Genes (Basel)       Date:  2021-07-26       Impact factor: 4.096

Review 2.  Innovative approaches for treatment of osteosarcoma.

Authors:  Emel Rothzerg; Abigail L Pfaff; Sulev Koks
Journal:  Exp Biol Med (Maywood)       Date:  2022-01-19

3.  Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer.

Authors:  Bingsheng Li; Yao He; Pan Li; Xiang Chen
Journal:  Front Genet       Date:  2021-11-11       Impact factor: 4.599

4.  Osteosarcoma subtypes based on platelet-related genes and tumor microenvironment characteristics.

Authors:  Yuan Shu; Jie Peng; Zuxi Feng; Kaibo Hu; Ting Li; Peijun Zhu; Tao Cheng; Liang Hao
Journal:  Front Oncol       Date:  2022-09-23       Impact factor: 5.738
  4 in total

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