Literature DB >> 29120642

Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis.

Luiz C Klein-Júnior1,2, Sylvian Cretton3, Pierre-Marie Allard3, Grégory Genta-Jouve4, Carolina S Passos3, Juliana Salton1, Pablo Bertelli1, Marion Pupier5, Damien Jeannerat5, Yvan Vander Heyden2, André L Gasper6, Jean-Luc Wolfender3, Philippe Christen3, Amélia T Henriques1.   

Abstract

Phytochemical investigation of the alkaloid extract of Palicourea sessilis by LC-HRMS/MS using molecular networking and an in silico MS/MS fragmentation approach suggested the presence of several new monoterpene indole alkaloids. These compounds were isolated by semipreparative HPLC, and their structures confirmed by means of HRMS, NMR, and ECD measurements as 4-N-methyllyaloside (3), 4-N-methyl-3,4-dehydrostrictosidine (4), 4β-hydroxyisodolichantoside (6), and 4α-hydroxyisodolichantoside (7), as well as the known alkaloids alline (1), N-methyltryptamine (2), isodolichantoside (5), and 5-oxodolichantoside (8). In addition, the acetylcholinesterase inhibitory activity of the compounds was evaluated up to 50 μM.

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Year:  2017        PMID： 29120642     DOI： 10.1021/acs.jnatprod.7b00681

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

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7.  Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes.

Authors:  Meri Emili F Pinto; Lai Yue Chan; Johannes Koehbach; Seema Devi; Carsten Gründemann; Christian W Gruber; Mario Gomes; Vanderlan S Bolzani; Eduardo Maffud Cilli; David J Craik
Journal:  J Nat Prod       Date:  2021-01-04       Impact factor: 4.050

8.  Application of HPLC-DAD for In Vitro Investigation of Acetylcholinesterase Inhibition Activity of Selected Isoquinoline Alkaloids from Sanguinaria canadensis Extracts.

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9.  Azepine-Indole Alkaloids From Psychotria nemorosa Modulate 5-HT2A Receptors and Prevent in vivo Protein Toxicity in Transgenic Caenorhabditis elegans.

Authors:  Benjamin Kirchweger; Luiz C Klein-Junior; Dagmar Pretsch; Ya Chen; Sylvian Cretton; André L Gasper; Yvan Vander Heyden; Philippe Christen; Johannes Kirchmair; Amélia T Henriques; Judith M Rollinger
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  9 in total

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