Literature DB >> 2911488

Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs.

W B Cruse1, J Aymani, O Kennard, T Brown, A G Jack, G A Leonard.   

Abstract

The structure of the synthetic deoxyoctamer d(GGIGCTCC) has been determined by single crystal X-ray diffraction techniques to a resolution of 1.7A. The sequence crystallises in space group P6(1), with unit cell dimensions a = b = 45.07, c = 45.49A. The refinement converged with a crystallographic residual R = 0.14 and the location of 81 solvent molecules. The octamer forms an A-DNA duplex with 6 Watson-Crick (G.C) base pairs and 2 inosine-thymine (I.T) pairs. Refinement of the structure shows it to be essentially isomorphous with that reported for d(GGGGCTCC) with the mispairs adopting a "wobble" conformation. Conformational parameters and base stacking interactions are compared to those for the native duplex d(GGGGCCCC) and other similar sequences. A rationale for the apparent increased crystal packing efficiency and lattice stability of the I.T octamer is given.

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Year:  1989        PMID： 2911488      PMCID： PMC331535          DOI： 10.1093/nar/17.1.55

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  14 in total

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Authors:  W Saenger; W N Hunter; O Kennard
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Authors:  B D Davis; P Anderson; P F Sparling
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Journal:  J Mol Biol       Date:  1984-09-25       Impact factor: 5.469

Review 5.  Helix geometry, hydration, and G.A mismatch in a B-DNA decamer.

Authors:  G G Privé; U Heinemann; S Chandrasegaran; L S Kan; M L Kopka; R E Dickerson
Journal:  Science       Date:  1987-10-23       Impact factor: 47.728

6.  Codon--anticodon pairing: the wobble hypothesis.

Authors:  F H Crick
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

7.  Inosine.adenine base pairs in a B-DNA duplex.

Authors:  P W Corfield; W N Hunter; T Brown; P Robinson; O Kennard
Journal:  Nucleic Acids Res       Date:  1987-10-12       Impact factor: 16.971

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Journal:  Nucleic Acids Res       Date:  1982-10-25       Impact factor: 16.971

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Authors:  T Brown; W N Hunter; G Kneale; O Kennard
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

10.  Structure of an adenine-cytosine base pair in DNA and its implications for mismatch repair.

Authors:  W N Hunter; T Brown; N N Anand; O Kennard
Journal:  Nature       Date:  1986 Apr 10-16       Impact factor: 49.962
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  18 in total

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Journal:  Nucleic Acids Res       Date:  1997-10-15       Impact factor: 16.971

6.  The synthesis and stability of oligodeoxyribonucleotides containing the deoxyadenosine mimic 1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide.

Authors:  W T Johnson; P Zhang; D E Bergstrom
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9.  The conformational variability of an adenosine.inosine base-pair in a synthetic DNA dodecamer.

Authors:  G A Leonard; E D Booth; W N Hunter; T Brown
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10.  Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA.

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