Lap Ho1, Kenjiro Ono2, Mayumi Tsuji3, Paolo Mazzola4, Risham Singh1, Giulio M Pasinetti1. 1. a Department of Neurology , Icahn School of Medicine at Mount Sinai , New York , NY , USA. 2. b Department of Neurology , Showa University School of Medicine , Tokyo , Japan. 3. c Department of Pharmacology , Showa University School of Medicine , Tokyo , Japan. 4. d Department of Medicine , Center for Neuroscience, University of Milano-Bicocca , Monza , Italy.
Abstract
BACKGROUND: Dietary fibers are metabolized by gastrointestinal (GI) bacteria into short-chain fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) mediated pathological processes that play key roles in Alzheimer's disease (AD) pathogenesis. RESEARCH DESIGN AND METHODS: Multiple complementary assays were used to investigate individual SCFAs for their dose-responsive effects in interfering with the assembly of Aβß1-40 and Aβ1-42 peptides into soluble neurotoxic Aβ aggregates. RESULTS: We found that several select SCFAs are capable of potently inhibiting Aβ aggregations, in vitro. CONCLUSION: Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates.
BACKGROUND: Dietary fibers are metabolized by gastrointestinal (GI) bacteria into short-chain fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) mediated pathological processes that play key roles in Alzheimer's disease (AD) pathogenesis. RESEARCH DESIGN AND METHODS: Multiple complementary assays were used to investigate individual SCFAs for their dose-responsive effects in interfering with the assembly of Aβß1-40 and Aβ1-42 peptides into soluble neurotoxic Aβ aggregates. RESULTS: We found that several select SCFAs are capable of potently inhibiting Aβ aggregations, in vitro. CONCLUSION: Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates.
Authors: Gal Bitan; Bogdan Tarus; Sabrina S Vollers; Hilal A Lashuel; Margaret M Condron; John E Straub; David B Teplow Journal: J Am Chem Soc Date: 2003-12-17 Impact factor: 15.419
Authors: Javier A Menendez; Alejandro Vazquez-Martin; Cristina Oliveras-Ferraros; Rocio Garcia-Villalba; Alegria Carrasco-Pancorbo; Alberto Fernandez-Gutierrez; Antonio Segura-Carretero Journal: Int J Mol Med Date: 2008-10 Impact factor: 4.101