Literature DB >> 33400081

Dysbiosis and Alzheimer's Disease: Cause or Treatment Opportunity?

Manuel H Janeiro1,2, María J Ramírez1,2, Maite Solas3,4.   

Abstract

Recent investigations have increased the interest on the connection between the microorganisms inhabiting the gut (gut microbiota) and human health. An imbalance of the intestinal bacteria representation (dysbiosis) could lead to different diseases, ranging from obesity and diabetes, to neurological disorders including Alzheimer's disease (AD). The term "gut-brain axis" refers to a crosstalk between the brain and the gut involving multiple overlapping pathways, including the autonomic, neuroendocrine, and immune systems as well as bacterial metabolites and neuromodulatory molecules. Through this pathway, microbiota can influence the onset and progression of neuropathologies such as AD. This review discusses the possible interaction between the gut microbiome and AD, focusing on the role of gut microbiota in neuroinflammation, cerebrovascular degeneration and Aβ clearance.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Entities:  

Keywords:  Alzheimer’s disease; Beta-amyloid; Blood-brain barrier; Gut microbiota; Neuroinflammation

Mesh：

Year:  2021        PMID： 33400081     DOI： 10.1007/s10571-020-01024-9

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  94 in total

Review 1.  The microbiota: an exercise immunology perspective.

Authors:  Stéphane Bermon; Bernardo Petriz; Alma Kajėnienė; Jonato Prestes; Lindy Castell; Octavio L Franco
Journal:  Exerc Immunol Rev       Date:  2015       Impact factor: 6.308

Review 2.  Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies.

Authors:  K J Anstey; N Cherbuin; M Budge; J Young
Journal:  Obes Rev       Date:  2011-02-23       Impact factor: 9.213

3.  Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans.

Authors:  Jacob M Allen; Lucy J Mailing; Grace M Niemiro; Rachel Moore; Marc D Cook; Bryan A White; Hannah D Holscher; Jeffrey A Woods
Journal:  Med Sci Sports Exerc       Date:  2018-04       Impact factor: 5.411

4.  Neonatal maternal deprivation promotes Nippostrongylus brasiliensis infection in adult rats.

Authors:  Frederick Barreau; Jacques Ducos de Lahitte; Laurent Ferrier; Jacques Frexinos; Lionel Bueno; Jean Fioramonti
Journal:  Brain Behav Immun       Date:  2005-08-31       Impact factor: 7.217

5.  Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome.

Authors:  Dora Abraham; Janos Feher; Gian Luca Scuderi; Dora Szabo; Arpad Dobolyi; Melinda Cservenak; Janos Juhasz; Balazs Ligeti; Sandor Pongor; Mari Carmen Gomez-Cabrera; Jose Vina; Mitsuru Higuchi; Katsuhiro Suzuki; Istvan Boldogh; Zsolt Radak
Journal:  Exp Gerontol       Date:  2018-12-06       Impact factor: 4.032

6.  Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats.

Authors:  F Barreau; L Ferrier; J Fioramonti; L Bueno
Journal:  Gut       Date:  2004-04       Impact factor: 23.059

7.  Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota.

Authors:  Sabine Bartosch; Alemu Fite; George T Macfarlane; Marion E T McMurdo
Journal:  Appl Environ Microbiol       Date:  2004-06       Impact factor: 4.792

8.  Microbiota modulation counteracts Alzheimer's disease progression influencing neuronal proteolysis and gut hormones plasma levels.

Authors:  Laura Bonfili; Valentina Cecarini; Sara Berardi; Silvia Scarpona; Jan S Suchodolski; Cinzia Nasuti; Dennis Fiorini; Maria Chiara Boarelli; Giacomo Rossi; Anna Maria Eleuteri
Journal:  Sci Rep       Date:  2017-05-25       Impact factor: 4.379

9.  SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model.

Authors:  Laura Bonfili; Valentina Cecarini; Massimiliano Cuccioloni; Mauro Angeletti; Sara Berardi; Silvia Scarpona; Giacomo Rossi; Anna Maria Eleuteri
Journal:  Mol Neurobiol       Date:  2018-02-28       Impact factor: 5.590

10.  microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration.

Authors:  Surjyadipta Bhattacharjee; Yuhai Zhao; Prerna Dua; Evgeny I Rogaev; Walter J Lukiw
Journal:  PLoS One       Date:  2016-03-07       Impact factor: 3.240
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  4 in total

1.  Introduction to the Special Issue "The Brain-Gut Axis".

Authors:  Yvette Taché; Juan M Saavedra
Journal:  Cell Mol Neurobiol       Date:  2021-10-15       Impact factor: 5.046

2.  Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice.

Authors:  Chenxi Tan; Yang Liu; Huiyi Zhang; Cihan Di; Dechao Xu; Chunming Liang; Ningning Zhang; Bing Han; Weiya Lang
Journal:  J Healthc Eng       Date:  2022-01-05       Impact factor: 2.682

Review 3.  Gut Microbiota Shifting in Irritable Bowel Syndrome: The Mysterious Role of Blastocystis sp.

Authors:  Alireza Olyaiee; Amir Sadeghi; Abbas Yadegar; Elnaz Sadat Mirsamadi; Hamed Mirjalali
Journal:  Front Med (Lausanne)       Date:  2022-06-20

Review 4.  The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease.

Authors:  Daniele Caligiore; Flora Giocondo; Massimo Silvetti
Journal:  IBRO Neurosci Rep       Date:  2022-09-26
  4 in total

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