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Literature DB >> 29094512

Genetics of type 1 diabetes.

Maria J Redondo¹, Andrea K Steck², Alberto Pugliese³.

Abstract

Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.

Entities: Disease Gene Mutation Species

Keywords: HLA; epidemiology; etiology; genetics; type 1 diabetes

Mesh：

Year: 2017 PMID： 29094512 PMCID： PMC5918237 DOI： 10.1111/pedi.12597

Source DB: PubMed Journal: Pediatr Diabetes ISSN： 1399-543X Impact factor: 4.866

126 in total

Review 1. Insights into type 1 diabetes provided by genetic analyses.

Authors: Grant Morahan
Journal: Curr Opin Endocrinol Diabetes Obes Date: 2012-08 Impact factor: 3.243

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Authors: Tamara S Hannon; Silva A Arslanian
Journal: Ann N Y Acad Sci Date: 2015-10-08 Impact factor: 5.691

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Authors: J Ilonen; M Kiviniemi; J Lempainen; O Simell; J Toppari; R Veijola; M Knip
Journal: Pediatr Diabetes Date: 2016-07 Impact factor: 4.866

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Journal: N Engl J Med Date: 2002-05-30 Impact factor: 91.245

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Authors: K H Lee; K W Wucherpfennig; D C Wiley
Journal: Nat Immunol Date: 2001-06 Impact factor: 25.606

6. Type 1 Diabetes TrialNet--an international collaborative clinical trials network.

Authors: Jay S Skyler; Carla J Greenbaum; John M Lachin; Ellen Leschek; Lisa Rafkin-Mervis; Peter Savage; Lisa Spain
Journal: Ann N Y Acad Sci Date: 2008-12 Impact factor: 5.691

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Authors: Andrea K Steck; Fran Dong; Randall Wong; Alexandra Fouts; Edwin Liu; Jihane Romanos; Cisca Wijmenga; Jill M Norris; Marian J Rewers
Journal: Pediatr Diabetes Date: 2013-11-08 Impact factor: 4.866

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Authors: Jason D Cooper; Deborah J Smyth; Adam M Smiles; Vincent Plagnol; Neil M Walker; James E Allen; Kate Downes; Jeffrey C Barrett; Barry C Healy; Josyf C Mychaleckyj; James H Warram; John A Todd
Journal: Nat Genet Date: 2008-11-02 Impact factor: 38.330

9. Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes.

Authors: M N Weedon; A T Hattersley; K A Patel; R A Oram; S E Flanagan; E De Franco; K Colclough; M Shepherd; S Ellard
Journal: Diabetes Date: 2016-04-05 Impact factor: 9.461

10. Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.

Authors: Lue Ping Zhao; Shehab Alshiekh; Michael Zhao; Annelie Carlsson; Helena Elding Larsson; Gun Forsander; Sten A Ivarsson; Johnny Ludvigsson; Ingrid Kockum; Claude Marcus; Martina Persson; Ulf Samuelsson; Eva Örtqvist; Chul-Woo Pyo; Wyatt C Nelson; Daniel E Geraghty; Åke Lernmark
Journal: Diabetes Date: 2016-01-06 Impact factor: 9.461

37 in total

Review 1. Interferon alpha: The key trigger of type 1 diabetes.

Authors: Angela Lombardi; Effie Tsomos; Sara S Hammerstad; Yaron Tomer
Journal: J Autoimmun Date: 2018-08-14 Impact factor: 7.094

Review 2. Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.

Authors: Laura M Jacobsen; Brittney N Newby; Daniel J Perry; Amanda L Posgai; Michael J Haller; Todd M Brusko
Journal: Curr Diab Rep Date: 2018-08-30 Impact factor: 4.810

Review 3. Zonulin as a potential putative biomarker of risk for shared type 1 diabetes and celiac disease autoimmunity.

Authors: Lauren K Wood Heickman; Mark D DeBoer; Alessio Fasano
Journal: Diabetes Metab Res Rev Date: 2020-03-31 Impact factor: 4.876

4. The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.

Authors: Maria J Redondo; Carmella Evans-Molina; Andrea K Steck; Mark A Atkinson; Jay Sosenko
Journal: Diabetes Care Date: 2019-06-04 Impact factor: 19.112

5. Increased islet antigen-specific regulatory and effector CD4⁺ T cells in healthy individuals with the type 1 diabetes-protective haplotype.

Authors: Xiaomin Wen; Junbao Yang; Eddie James; I-Ting Chow; Helena Reijonen; William W Kwok
Journal: Sci Immunol Date: 2020-02-14

6. Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population.

Authors: Rossana Santiago de Sousa Azulay; Luís Cristóvão Porto; Dayse Aparecida Silva; Maria da Glória Tavares; Roberta Maria Duailibe Ferreira Reis; Gilvan Cortês Nascimento; Sabrina da Silva Pereira Damianse; Viviane Chaves de Carvalho Rocha; Marcelo Magalhães; Vandilson Rodrigues; Paulo Ricardo Vilas Boas Carvalho; Manuel Dos Santos Faria; Marília Brito Gomes
Journal: Sci Rep Date: 2021-07-08 Impact factor: 4.379