Literature DB >> 18978792

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Jason D Cooper1, Deborah J Smyth, Adam M Smiles, Vincent Plagnol, Neil M Walker, James E Allen, Kate Downes, Jeffrey C Barrett, Barry C Healy, Josyf C Mychaleckyj, James H Warram, John A Todd.   

Abstract

We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).

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Year:  2008        PMID： 18978792      PMCID： PMC2635556          DOI： 10.1038/ng.249

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

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