Literature DB >> 11376336

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.

K H Lee1, K W Wucherpfennig, D C Wiley.   

Abstract

The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.

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Year:  2001        PMID： 11376336     DOI： 10.1038/88694

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  130 in total

1.  Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life.

Authors:  G K Papadopoulos; C Wijmenga; F Koning
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

2.  Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition.

Authors:  Anish Suri; James J Walters; Osami Kanagawa; Michael L Gross; Emil R Unanue
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

3.  Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.

Authors:  Brian D Stadinski; Li Zhang; Frances Crawford; Philippa Marrack; George S Eisenbarth; John W Kappler
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-01       Impact factor: 11.205

4.  Alternate interactions define the binding of peptides to the MHC molecule IA(b).

Authors:  Xinqi Liu; Shaodong Dai; Frances Crawford; Rachel Fruge; Philippa Marrack; John Kappler
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-25       Impact factor: 11.205

5.  Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

Authors:  Christian Siebold; Bjarke E Hansen; Jessica R Wyer; Karl Harlos; Robert E Esnouf; Arne Svejgaard; John I Bell; Jack L Strominger; E Yvonne Jones; Lars Fugger
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-09       Impact factor: 11.205

Review 6.  Molecular aspects of type 1 diabetes.

Authors:  M A Kelly; M L Rayner; C H Mijovic; A H Barnett
Journal:  Mol Pathol       Date:  2003-02

7.  A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.

Authors:  Zarixia Zavala-Ruiz; Iwona Strug; Bruce D Walker; Philip J Norris; Lawrence J Stern
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-26       Impact factor: 11.205

8.  Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.

Authors:  Chu-Young Kim; Hanne Quarsten; Elin Bergseng; Chaitan Khosla; Ludvig M Sollid
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-12       Impact factor: 11.205

9.  Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire.

Authors:  Menno van Lummel; Peter A van Veelen; Arnaud Zaldumbide; Arnoud de Ru; George M C Janssen; Antonis K Moustakas; George K Papadopoulos; Jan W Drijfhout; Bart O Roep; Frits Koning
Journal:  J Biol Chem       Date:  2011-12-19       Impact factor: 5.157

10.  Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.

Authors:  Thomas Stratmann; Natalia Martin-Orozco; Valérie Mallet-Designe; Laurent Poirot; Dorian McGavern; Grigoriy Losyev; Cathleen M Dobbs; Michael B A Oldstone; Kenji Yoshida; Hitoshi Kikutani; Diane Mathis; Christophe Benoist; Kathryn Haskins; Luc Teyton
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808
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